Fig 7. Combination of fluconazole and bradykinin increased survival of C. albicans infected mice.

(A) Experimental design for combinatorial fluconazole and bradykinin therapy strategy (B) WT mice (n = 16) were infected with C. albicans. Infected mice were treated with two doses of FLC only (5 mg/kg at 2 and 24 h p.i.), bradykinin only (300nmol/kg starting 1 day prior to infection and daily for 14 days) or a combination of FLC and bradykinin. Sham-infected mice (n = 3) were treated with FLC, bradykinin or both. Survival was assessed over 14 d. Data are combined from 3 independent experiments. p<0.05 (*), p>0.001 (***), p>0.0001 (****).