Table 2.
Characterization of the hydrodynamic diameter, ζ potential, EE, and LC of the SLN, NLC, EGCG-SLN, and EGCG-NLC formulations
| Sample | Z-average (nm) | Polydispersity index | ζ potential (mV) | Entrapment efficiency (%) | Loading capacity (%) |
|---|---|---|---|---|---|
| SLN | 206±3 | 0.18±0.01 | −28±1 | NA | NA |
| EGCG-SLN | 364±11a | 0.19±0.03 | −24±1 | 83±1 | 4.3±0.1 |
| NLC | 216±4 | 0.16±0.02 | −30±1 | NA | NA |
| EGCG-NLC | 300±7b,c | 0.15±0.02 | −28±1 | 90±1 | 4.6±0.1 |
Notes: All values represent the mean ± standard deviation (n=3).
a
Statistically different (P<0.05) between SLN and EGCG-loaded SLN.
b
Statistically different (P<0.05) between NLC and EGCG-loaded NLC.
c
Statistically different (P<0.05) between EGCG-loaded SLN and NLC.
Abbreviations: EE, encapsulation efficiency; EGCG, epigallocatechin gallate; EGCG-NLC, epigallocatechin gallate loaded nanostructured lipid carriers; EGCG-SLN, epigallocatechin gallate loaded solid lipid nanoparticles; LC, drug-loading capacity; NA, not applicable; NLC, nanostructured lipid carriers; SLN, solid lipid nanoparticles.