Table 1.
The main characteristics of included studies in this meta-analysis
| References | Year | Country | Ethnicity | Method | Sample type | Case
|
Control
|
Control source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| M | Total | M | Total | |||||||
| Saito et al27 | 1998 | Japan | Asian | MSRE | Tissue | 9 | 52 | 0 | 52 | Autologous |
| Yeh et al38 | 2002 | People’s Republic of China | Asian | MSP | Tissue | 41 | 48 | 16 | 48 | Autologous |
| Chang et al26 | 2002 | People’s Republic of China | Asian | MSRE | Tissue | 45 | 70 | 0 | 11 | Heterogeneous |
| Viswanathan et al37 | 2003 | India | African | MSRE | Tissue | 35 | 99 | 0 | 25 | Autologous |
| Shaw et al29 | 2006 | UK | Caucasian | Pyrosequencing | Tissue | 30 | 71 | 6 | 18 | Autologous |
| de Moraes et al39 | 2008 | Brazil | Caucasian | MSP | Tissue | 27 | 46 | 0 | 5 | Heterogeneous |
| Righini et al40 | 2007 | France | Caucasian | MSP | Tissue | 32 | 90 | 0 | 30 | Autologous |
| Steinmann et al41 | 2009 | Germany | Caucasian | MSP | Tissue | 23 | 54 | 2 | 23 | Autologous |
| Su et al42 | 2010 | People’s Republic of China | Asian | MSP | Tissue | 21 | 31 | 12 | 31 | Autologous |
| Kordi-Tamandani et al43 | 2010 | Iran | Caucasian | MSP | Tissue | 47 | 76 | 31 | 57 | Heterogeneous |
| Weiss et al16 | 2011 | Germany | Caucasian | MSP | Tissue | 13 | 37 | 7 | 31 | Heterogeneous |
| Supic et al28 | 2011 | Serbia | Caucasian | MSP | Tissue | 20 | 47 | 6 | 47 | Autologous |
| Nagata et al44 | 2012 | Japan | Asian | MSP | Rinse | 32 | 34 | 5 | 24 | Heterogeneous |
| Xu et al47 | 2012 | People’s Republic of China | Asian | MSP | Tissue | 22 | 60 | 2 | 50 | Heterogeneous |
| Asokan et al45 | 2014 | India | African | MSP | Tissue | 6 | 10 | 0 | 5 | Heterogeneous |
| Mielcarek-Kuchta et al46 | 2014 | Poland | Caucasian | MSP | Tissue | 24 | 53 | 14 | 53 | Autologous |
| Choudhury and Ghosh15 | 2015 | India | African | MSP | Tissue | 23 | 71 | 4 | 45 | Autologous |
| Hasegawa et al50 | 2002 | USA | Caucasian | MSP | Tissue | 29 | 80 | na | na | na |
| Calmon et al48 | 2007 | Brazil | Caucasian | MSP | Tissue | 38 | 43 | na | na | na |
| Dikshit et al49 | 2007 | France | Caucasian | MSP | Tissue | 82 | 190 | na | na | na |
| Marsit et al51 | 2008 | USA | Caucasian | MSP | Tissue | 113 | 340 | na | na | na |
| Supic et al52 | 2009 | Serbia | Caucasian | nMSP | Tissue | 33 | 77 | na | na | na |
| Pannone et al21 | 2014 | Italy | Caucasian | MSP | Tissue | 14 | 48 | na | na | na |
Notes: Autologous: control from the HNSCC group; Heterogeneous: control from other individuals.
Abbreviations: M, methylation; MSRE, methylation-sensitive restriction endonuclease; MSP, methylation-specific polymerase chain reaction; nMSP, nested methylation-specific polymerase chain reaction; na, not available; HNSCC, head and neck squamous cell carcinoma.