Table 4.
The association between and CDH1 promoter methylation and the clinicopathological features in HNSCC
| Characteristics | Noa | Case/control types | Cases/controls | OR (95% CI) | P-value | I2% |
|---|---|---|---|---|---|---|
| Age | 4 | Older/younger | 354/329 | 0.84 (0.61–1.15) | 0.277 | 0 |
| Gender | 5 | Male/female | 560/156 | 0.82 (0.55–1.20) | 0.306 | 0 |
| Smoking behavior | 5 | Yes/no | 523/128 | 1.14 (0.76–1.70) | 0.539 | 29.8 |
| Alcohol consumption | 2 | Yes/no | 40/62 | 6.04 (2.41–15.14) | <0.001 | 0 |
| Differentiation grade | 4 | Well/moderate or poor | 61/115 | 0.42 (0.08–2.24) | 0.312 | 56.7 |
| Tumor stage | 6 | T1+2/T3+4 | 139/234 | 0.46 (0.27–0.78) | 0.004 | 26.8 |
| Clinical stage | 4 | I + II/III + IV | 65/170 | 0.63 (0.33–1.18) | 0.149 | 25 |
| Lymph node metastasis | 6 | Yes/no | 191/182 | 0.93 (0.56–1.56) | 0.794 | 41.4 |
Note:
a
The number of included studies.
Abbreviations: CI, confidence interval; OR, odds ratio; HNSCC, head and neck squamous cell carcinoma.