Table 1.

Enantioselective Oxocarbenium Alkylation Enabled by Designed Catalyst Me-1.^a

entry	nucleophile	time (h)	cat.	conv (%)b	ee (%)
1	3a	4	1	66	92c
2			Me-1	>95	97c
3	3b	1	1	81	85d
4			Me-1	91	91d
5	3c	24	1	82	88d
6			Me-1	>95	96d

^aReactions were run on 0.2 or 0.3 mmol scale and quenched after the designated time with 0.5 M NaOMe in MeOH. See footnote 12.

^bConversion was determined from the relative integration of the ¹H NMR resonances of the product and quenched α-methoxyisochroman.

^cDetermined by CSP-GC.

^dDetermined by CSP-HPLC.