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. Author manuscript; available in PMC: 2017 Oct 4.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Jun 22;55(41):12596–12624. doi: 10.1002/anie.201600547

Table 1.

The table shows the reaction enantioselectivity as a function of the electronic properties of the aromatic group on the catalyst.

Entry Catalyst [a] QZZ Iminium Ion Mole Fraction:
ee[b] (%)
41x-i 41x-ii 41x-iii
1 39b +3.01 0.37 0.16 0.47 65
2 39c +0.28 0.39 0.21 0.40 70
3 39a −3.46 0.75 0.03 0.23 84
4 39d −3.71 0.76 0.04 0.20 90
5 39e −5.68 0.65 0.17 0.18 94
6 40 −3.46 -- -- -- 85
[a]

See the catalyst substitution pattern in Scheme 12.

[b]

Enantiomeric excess of 44d, formed by the reaction shown in Scheme 12.