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. Author manuscript; available in PMC: 2016 Nov 4.
Published in final edited form as: Biotechnol Bioeng. 2015 Sep 2;112(12):2562–2570. doi: 10.1002/bit.25681

Figure 5.

Figure 5

Schematic of proposed mechanism of the combined effect of antibiotic and hyperosmotic agents. An increased hyperosmotic compound concentration is expected to increase the osmotic effect. However, increasing concentration of hyperosmotic compound also reduces the diffusion of molecules inside the biofilm. Therefore, a high dosage of a hyperosmotic compound can be counterproductive.