Table 2.
Risk of Incident Fracture Given Different Clinical Risk Factors in Diabetic Women and Nondiabetic Women
| Risk factor | Women with diabetes
|
Women without diabetes
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p Value | HR | 95% CI | p Value | |
| Prior osteoporotic fracture | 1.69 | 1.23–2.31 | 0.001 | 1.79 | 1.44–2.24 | <0.001 |
| Age increase per 10 yr | 1.24 | 1.05–1.47 | 0.011 | 1.42 | 1.26–1.61 | <0.001 |
| BMI increase per SD | 0.80 | 0.69–0.93 | 0.003 | 0.93 | 0.82–1.06 | 0.276 |
| FN BMD decrease per SD | 1.52 | 1.40–1.81 | <0.001 | 1.71 | 1.61–1.96 | <0.001 |
| COPD | 1.29 | 0.86–1.93 | 0.222 | 0.99 | 0.72–1.36 | 0.953 |
| Substance use | 1.18 | 0.46–3.00 | 0.728 | 1.99 | 1.20–3.32 | 0.008 |
| Rheumatoid arthritis | 1.49 | 0.78–2.85 | 0.225 | 1.16 | 0.75–1.80 | 0.510 |
| Hyperthyroidism | 0.95 | 0.39–2.31 | 0.911 | 0.67 | 0.33–1.35 | 0.261 |
| Dementia | 1.59 | 0.72–3.49 | 0.251 | 1.89 | 1.19–3.01 | 0.007 |
| Systemic corticosteroid use | 1.00 | 0.56–1.80 | 0.990 | 1.66 | 1.11–2.48 | 0.014 |
| Osteoporosis medication use | 0.74 | 0.50–1.09 | 0.125 | 1.02 | 0.82–1.28 | 0.852 |
Abbr: HR, hazard ratio; CI, confidence interval; BMI, body mass index; SD, standard deviation; FN, femoral neck; BMD, bone mineral density; COPD, chronic obstructive pulmonary disease.