Table 5.
Observed Fracture Probability at 10 Yr (Kaplan-Meier Estimate) According to FRAX Major Osteoporotic Fracture Category Before and After Risk Reclassification Using the Sex- and Age-Adjusted Rounded Offset Adjustment
| FRAX (No offset adjustment) | FRAX (With offset adjustment)
|
||||
|---|---|---|---|---|---|
| Overall | Low | Moderate | High | p Trend* | |
| Low (<10%) | |||||
| N total | 4443 | 4327 | 116 | 0 | |
| N fracture | 277 | 258 | 19 | 0 | <0.001 |
| Estimated fracture probability at 10 yr (%) | 6.8 | 6.5 | 18.1 | — | |
| Total reclassified | 1.8% | — | 1.8% | 0.0% | |
| Moderate (10–20%) | |||||
| N total | 1476 | 125 | 1286 | 65 | |
| N fracture | 217 | 9 | 195 | 13 | 0.008 |
| Estimated fracture probability at 10 yr (%) | 16.1 | 7.5 | 16.6 | 22.1 | |
| Total reclassified | 3.0% | 2.0% | — | 1.0% | |
| High (>20%) | |||||
| N total | 469 | 0 | 38 | 431 | |
| N fracture | 107 | 0 | 10 | 97 | 0.592 |
| Estimated fracture probability at 10 yr (%) | 25.4 | — | 28.7 | 25.1 | |
| Total reclassified | 0.6% | 0.0% | 0.6% | — | |
| Total | |||||
| N total | 6388 | 4452 | 1440 | 496 | |
| N fracture | 601 | 267 | 224 | 110 | <0.001 |
| Estimated fracture probability at 10 yr (%) | 10.3 | 6.6 | 17.0 | 24.7 | |
| Total reclassified | 5.4% | 2.0% | 2.4% | 1.0% | |
*
p Trend is from the Cochran-Armitage test.