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Structure activity relationships of paraben-liked molecules on fatty acid amide hydrolase (FAAH) inhibition.
| ||||
|---|---|---|---|---|
| Compound | R1 | R2 | X | IC50 (μM) (5 min pre-incubation) |
| Benzylparaben |
|
|
O | 0.14 ± 0.03 |
| 1 |
|
|
O | 18.2 ± 4.9 |
| 2 |
|
|
O | >100 |
| 3 |
|
|
O | >100 |
| 4 |
|
|
O | >100 |
| 5 |
|
|
O | 0.36 ± 0.03 |
| 6 |
|
|
O | 0.15 ± 0.04 |
| 7 |
|
|
N | 8.6 ± 1.3 |
