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. Author manuscript; available in PMC: 2017 Nov 16.

Published in final edited form as: Toxicol Lett. 2016 Sep 19;262:92–99. doi: 10.1016/j.toxlet.2016.09.011

Table 3.

Relative selectivity of butylparaben and benzylparaben on FAAH in rodent species and on other recombinant enzymes.

Enzyme Source	IC₅₀ (μM) (5 min pre-incubation)
	URB597	Butylparaben	Benzylparaben
Human Recombinant hCE1^b	2.2	>10	>10
Human Recombinant hCE2^b	0.73	>10	>10
Human Recombinant AADAC^b	>10	>10	>10
Human Recombinant FAAH^a	0.040 ± 0.011	1.1 ± 0.2	0.14 ± 0.03
Mouse Brain Microsomes^a	<0.001	1.6	0.21
Rat Brain Microsomes^a	0.005	1.1	0.23

^a

Measured by hydrolysis of OMP, [S] = 50 μM.

^b

Measured by hydrolysis of CMNA, [S] = 50 μM.