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. Author manuscript; available in PMC: 2017 Nov 3.
Published in final edited form as: Mol Cell. 2016 Oct 20;64(3):443–454. doi: 10.1016/j.molcel.2016.09.015

Figure 6. Severing the kinase module from Mediator increases Mediator occupancy at the enhancer but not the core promoter.

Figure 6

(A) Med6 and Med3 occupancies at the indicated enhancers and core promoters in a strain deleted for Med13 or Cdk8 before or after Kin28 depletion.

(B) Mean Pol II occupancy curves (aligned by the TSS) for the ~450 most active genes in cells that were (+rap) or were not (−rap) depleted for Cdk8.