Table 3.

Final multivariable model of risk factors for healthcare facility-onset Clostridium difficile infection in the ICU.

Risk Factors	Adjusted HR (95% CI)
ICU Type
Medical	Ref
Surgical	1.05 (0.76–1.46)
Cardiac	0.89 (0.60–1.31)
Neurological	1.50 (1.01–2.23)
Creatinine (per mg/dl increase)	1.09 (1.02–1.16)
Albumin (per g/dl increase)	0.93 (0.77–1.12)
Charlson comorbidity index
0–2	Ref
3+	1.34 (1.00–1.79)
Mechanical ventilation	1.31 (0.96–1.77)
Hemodialysis	1.14 (0.79–1.64)
Proton pump inhibitors	1.29 (0.62–2.70)
Antibiotics	2.79 (1.50–5.19)

ICU, intensive care unit; HR, hazard ratio; CI, confidence interval. The model includes an interaction term for proton pump inhibitors and antibiotics.