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. Author manuscript; available in PMC: 2017 Nov 30.
Published in final edited form as: Stat Med. 2016 Aug 31;35(27):4924–4936. doi: 10.1002/sim.7095

Table 1.

Escalation and de-escalation boundaries λ1 and λ2 for the BOIN design under different target toxicity rates

Boundaries Target toxicity rate ϕT
0.15 0.2 0.25 0.3 0.35 0.4
λ1 0.118 0.157 0.197 0.236 0.276 0.316
λ2 0.179 0.238 0.298 0.358 0.419 0.479