Table 5.
The percentage of correct selection of the MTD contour, and the percentage of patients treated above and at the MTD contour.
| Design | Scenario
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | |
| % correct selection of the MTD contour | ||||||||||||||
| Waterfall | 50.4 | 36.4 | 35.1 | 48.5 | 18.7 | 27.7 | 36.8 | 36.0 | 30.7 | 32.6 | 33.8 | 35.9 | 31.3 | 38.4 |
| PIPE | 20.5 | 19.6 | 10.2 | 44.5 | 8.9 | 6.1 | 12.5 | 12.5 | 11.9 | 10.1 | 10.9 | 12.2 | 11.6 | 15.8 |
| % of patients treated above the MTD contour | ||||||||||||||
| Waterfall | 9.4 | 25.0 | 12.7 | 51.7 | 30.0 | 16.2 | 34.4 | 24.6 | 14.2 | 16.0 | 15.7 | 33.2 | 26.2 | 36.0 |
| PIPE | 5.8 | 16.7 | 8.6 | 40.4 | 51.7 | 25.8 | 62.0 | 46.6 | 18.4 | 24.4 | 30.2 | 51.1 | 46.7 | 54.9 |
| % of patients treated at the MTD contour | ||||||||||||||
| Waterfall | 51.3 | 50.1 | 47.8 | 48.3 | 44.1 | 53.6 | 48.0 | 39.3 | 45.7 | 46.2 | 48.0 | 42.6 | 39.5 | 47.0 |
| PIPE | 48.0 | 59.2 | 51.5 | 59.6 | 37.4 | 54.5 | 27.4 | 29.1 | 47.2 | 43.3 | 43.1 | 31.2 | 28.8 | 34.0 |
| Sample size (matched between two designs) | ||||||||||||||
| 27 | 27 | 27 | 18 | 48 | 60 | 36 | 36 | 60 | 60 | 60 | 42 | 42 | 39 | |