Table 6.

Selection probability and number of patients treated at each dose combination using the proposed phase I/II waterfall design, with the target dose combinations in boldface.

Sc.	Drug A	Drug B						Simulation results
		True pr(toxicity)			True pr(efficacy)			Selection percentage			No selection†	Number of patients
		1	2	3	1	2	3
1	2	0.10	0.30	0.50	0.25	0.35	0.55	7.5	20.2	0.9	0.5	11.6	19.5	4.9
	1	0.03	0.10	0.28	0.20	0.30	0.50	0.1	20.2	50.6		3.5	9.1	22.2
2	2	0.10	0.30	0.50	0.20	0.30	0.40	23.5	42.0	0.9	11.0	11.3	18.8	5.0
	1	0.03	0.10	0.28	0.07	0.12	0.20	0.0	3.3	19.3		3.5	7.9	22.3
3	2	0.10	0.30	0.50	0.25	0.50	0.60	7.9	36.1	0.9	0.5	12.0	19.3	4.9
	1	0.03	0.10	0.28	0.20	0.32	0.50	0.3	14.4	39.9		3.5	8.6	22.3
4	2	0.10	0.30	0.50	0.04	0.07	0.10	1.1	5.7	0.3	92.5	7.5	12.5	4.7
	1	0.03	0.10	0.28	0.01	0.03	0.05	0.0	0.0	0.4		3.4	4.3	15.4
5	2	0.30	0.48	0.60	0.40	0.45	0.49	36.0	2.6	0.0	10.9	18.6	5.4	0.7
	1	0.12	0.30	0.48	0.20	0.40	0.60	16.2	32.1	2.2		13.3	21.0	5.4
6	2	0.30	0.48	0.60	0.36	0.50	0.60	51.9	2.8	0.0	42.6	19.3	5.5	0.7
	1	0.12	0.30	0.48	0.01	0.06	0.10	2.0	0.6	0.1		8.8	16.6	5.0
7	2	0.32	0.45	0.60	0.50	0.55	0.63	45.6	4.7	0.1	47.7	18.0	5.9	0.9
	1	0.10	0.15	0.30	0.01	0.02	0.03	1.9	0.0	0.0		7.8	9.3	14.1
8	2	0.42	0.49	0.55	0.17	0.33	0.55	3.4	0.6	0.1	88.9	6.8	1.6	0.2
	1	0.30	0.40	0.50	0.06	0.22	0.39	2.4	4.4	0.2		12.8	5.8	1.4

^†“No selection” is the percentage that the method did not select any dose-combination as the optimal dose.