Table 1.
Mastoparan-induced cytotoxicity toward a panel of normal cells and cancer cells
| % Cytotoxicitya,c | % Hemolysisb,c | ||||
|---|---|---|---|---|---|
| [Mastoparan] | Jurkat | MDA-MB-231 | PBMCs | HMECs | Erythrocytes |
| 10 μM | 64 ± 7 | 20 ± 1 | 13 ± 5 | 16 ± 1 | 1 ± 1 |
| 25 μM | 95 ± 4 | 62 ± 2 | 29 ± 7 | 37 ± 7 | 2 ± 1 |
| 50 μM | 97 ± 1 | 96 ± 1 | 49 ± 3 | 67 ± 14 | 7 ± 1 |
a
Mastoparan-induced cytotoxicity was determined by MTT assay after 24 h.
b
Hemolytic activity toward human erythrocytes was determined by hemolysis assay after 4 h.
c
Data shown represent the mean of 3 independent experiments ± SEM.