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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Pharm Res. 2016 Sep 12;33(12):2954–2966. doi: 10.1007/s11095-016-2017-y

Table II.

Summary of scFv7F9Cys and scFv7F9Cys-PEG20K pharmacokinetic properties.

scFv7F9Cys scFv7F9Cys-PEG Fold Change p-value
AUC (ng*hr/ml) 181672 ± 10848 7721296 ± 555294 43 <0.0001
Cls (ml/hr*kg) 201 ± 9 4 ± 0.3 −46 <0.0001
Vdbeta (ml/kg) 270 ± 27 164 ± 40 −2 <0.05
t½ (hrs) 0.9 ± 0.08 25 ± 0.005 27 <0.0001