Table 3.
Patients | Gain/loss | Genes |
---|---|---|
1, 2, 6 | Gain 2p24.3 | TRIB2 (oncogene that inactivates the transcription factor C/EBPalpha and causes acute myelogenous leukemia) |
2, 4, 6 | Gain 3q29 | MFI2 (cell-surface glycoprotein found on melanoma cells) |
2, 4, 6 | Gain 10q11.21 | RET (Proto-oncogene. Diseases associated include familial papillary thyroid carcinoma) |
2, 4, 6 | Gain 12q13.12 |
WNT1 (secreted signaling protein. Implicated in oncogenesis), DDN (promotes apoptosis of kidney glomerular podocytes), PRKAG1 (Regulatory subunit of the AMP-activated protein kinase) |
1, 2, 6 | Gain 21q22.12 | RUNX1 (involved in the development of normal hematopoiesis. Diseases associated include familial platelet disorder with associated myeloid malignancy) |
2, 4, 6 | Gain Xq21.1 | BRWD3 (chromatin-modifying function. Diseases associated include chronic lymphocytic leukemia) |
2, 4, 6 | Gain Xq25 | GRIA3 (receptor for glutamate) |
2, 4, 6 | Gain Xq25 | XIAP (oncogene. Diseases associated include chronic neutrophilic leukemia) |