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. 2016 Mar 22;266(8):725–736. doi: 10.1007/s00406-016-0684-7

Table 4.

Proposed criteria for DSM-5 mixed anxiety depression [from 17, Appendix II]

(1) The patient has three or four of the following symptoms for at least 2 weeks, one of which must be (a) or (b)
 (a) Depressed mood most of the day, almost every day, as indicated by either subjective report (e.g., feels sad or empty) or observation made by others (e.g., appears tearful)
 (b) Markedly diminished interest or pleasure in all, or almost all, activities most of the day, almost every day
 (c) Significant weight loss when not dieting or weight gain (e.g., a change of more than 5 % of body weight in 1 month), or decrease or increase in appetite almost every day
 (d) Insomnia or hypersomnia almost every day
 (e) Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down)
 (f) Fatigue or loss of energy nearly every day
 (g) Feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick)
 (h) Diminished ability to think or concentrate, or indecisiveness, almost every day (either by subjective account or as observed by others)
 (i) Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide
(2) The symptoms in (1) are accompanied by two (or more) of the following symptoms of anxious distress, also lasting at least 2 weeks:
 (a) Irrational worry
 (b) Preoccupation with unpleasant worries
 (c) Having trouble relaxing
 (d) Motor tension
 (e) Fear that something awful would happen
(3) No other DSM diagnosis of anxiety or depression is present