Table 2.

Effect of bromocriptine.

	Lean subjects			Obese subjects
	Pre-exposure	Post-exposure	P value	Pre-exposure	Post-exposure	P value
Glucose AUCm (mmol/L * 120 min)	664 (584–767)	670 (595–784)	0.484	748 (674–868)	669 (620–734)	0.069
Insulin AUCm (pmol/L * 120 min)	29,029 (22,069–38,126)	24,879 (15,893–38,851)	0.779	55,900 (43,236–96,831)	36,448 (25,213–57,711)	0.012
HOMA-IRm	0.36 (0.18–0.68)	0.59 (0.18–1.1)	0.161	2.46 (1.19–5.77)	2.10 (0.92–4.25)	0.263
HOMA-IR AUCm	1181 (797–1449)	1076 (578–1560)	0.674	2405 (1649–4655)	1229 (896–2348)	0.012
Glucose AUCe (mmol/L * 120 min)	742 (695–818)	641 (504–750)	0.036	735 (614–988)	644 (568–829)	0.017
Insulin AUCe (pmol/L * 120 min)	32,836 (18,823–42,053)	25,698 (24,244–42,143)	0.575	35,446 (23,694–52,771)	38,390 (25,664–104,861)	0.208
HOMA-Ire	0.35 (0.20–0.65)	0.42 (0.18–0.79)	0.036	1.43 (0.29–3.78)	2.24 (1.20–3.25)	0.093
HOMA-IR AUCe	1198 (799–1731)	975 (714–1290)	0.263	1296 (828–2666)	1356 (931–5359)	0.401
EEm (kcal/day)	1673 (1441–1893)	1539 (1431–1925)	0.889	2047 (1890–2214)	2011 (1814–2305)	0.327
EEe (kcal/day)	1694 (1542–2009)	1666 (1473–1784)	0.208	1996 (1940–2304)	2211 (1887–2356)	0.575
RQm	0.78 (0.76–0.81)	0.79 (0.76–0.85)	0.401	0.81 (0.76–0.90)	0.80 (0.79–0.85)	0.889
RQe	0.80 (0.79–0.84)	0.78 (0.75–0.80)	0.161	0.83 (0.80–0.85)	0.82 (0.79–0.91)	0.833
Weight m (kg)	71.4 (6301–79.3)	70.7 (63.3–80.0)	0.399	103.6 (95.9–131.4)	104.3 (96.6–133.5)	0.176
Weight e (kg)	70.1 (64.3–80.2)	70.7 (64.5–80.8)	0.176	104.3 (97.9–133.3)	105.4 (96.4–134.1)	0.865

Absolute effect of administration of bromocriptine compared with its prior pre-exposure visit. Data presented as n or as median (interquartile ranges). Differences between visits were calculated with the Wilcoxon signed-rank test. HOMA-IR, homeostatic model assessment – insulin resistance, calculated as (glucose (mmol/L) × insulin (U/L))/(22.5). m: outcome after treatment with bromocriptine in the morning. e: outcome after treatment with bromocriptine in the evening. AUC, area under the curve; EE, energy expenditure; RQ, respiratory quotient. Bold indicated statistical significance (P < 0.05).