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Deletion of mTORC1 suppresses age-associated elevation of MPV and MK size in mice. (A) Complete blood count analysis of 4-, 12-, and 16-month-old WT and Raptor KO mice. MPV (A) and platelet (PLT) (B) counts are shown (n = 8). Values represent means ± SEM; *P < .05; **P < .01. (C) VWF IHC staining of femur bone sections from 4- and 12-month-old WT and Raptor KO mice. Bar represents 100 μm. Quantification of number, no. MK/T.Ar(/mm2), (D) and MK size (E). *P < .05.
