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A, Experimental design for thoracic aortic aneurysm prevention in wild-type mice with anakinra. B, Anakinra pretreatment significantly decreased aortic dilation compared with pretreatment with vehicle only. C, Anakinra-pretreated mice had increased elastin and smooth muscle cell staining, along with decreased macrophage and neutrophil staining. Scale bar, 50 μm.
