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. Author manuscript; available in PMC: 2017 Jan 14.
Published in final edited form as: Gene Ther. 2016 Jul 14;23(11):767–774. doi: 10.1038/gt.2016.54

Figure 6.

Figure 6

GFP fluorescence following ex vivo administration of AAV vectors in human retinal tissue. GFP expression in explants following rAAV 2/2 (a), rAAV2/2 Y44F (b) and rAAV2/8 Y733F (c) exposure. Histological cross-sections of specimens show expression of GFP (green, panel i) and merge with DAPI (blue, panel ii) for each vector. Images d shows colocalisation of GFP (green) in bipolar cells identified by PKC alpha immunostaining (red) demonstrating human bipolar cell transduction. GCL= ganglion cell layer; INL= inner nuclear layer, ONL= outer nuclear layer. Scale bar 50μm for images a-c, 10μm for images d.