Computational modeling of a leukocyte interacting with surfaces coated with different numbers of HNt demonstrates that leukocytes, distinct in their expression of microvilli (Mv) maintain a low molecular contact area, or area of direct physical contact, with the surface (3 Mv, blue solid line) compared to a smooth cell (0 Mv, red dashed line) despite increasing numbers of HNt (A). HNt were generated based on random distributions of length, diameter, location, and orientation on the surface (B).