Table 5.
Tumour CD274 expression and colorectal cancer patient mortality
| Tumour CD274 expression score | Total No. | Colorectal cancer-specific
mortality |
Overall mortality |
||||
|---|---|---|---|---|---|---|---|
| No. of events | Univariable HR (95% CI) | Multivariable HR (95% CI)* | No. of events | Univariable HR (95% CI) | Multivariable HR (95% CI)* | ||
| 0 | 91 | 24 | 1 (reference) | 1 (reference) | 47 | 1 (reference) | 1 (reference) |
| 1 | 230 | 70 | 1.18 (0.74–1.87) | 1.00 (0.63–1.60) | 121 | 1.00 (0.71–1.40) | 0.89 (0.63–1.25) |
| 2 | 216 | 61 | 1.10 (0.68–1.76) | 1.00 (0.62–1.60) | 117 | 1.08 (0.77–1.51) | 1.02 (0.72–1.43) |
| 3 | 235 | 79 | 1.28 (0.81–2.03) | 0.95 (0.60–1.52) | 139 | 1.06 (0.76–1.48) | 0.96 (0.68–1.34) |
| 4 | 43 | 12 | 1.06 (0.53–2.12) | 0.64 (0.32–1.28) | 26 | 1.03 (0.64–1.66) | 0.73 (0.45–1.19) |
| Ptrend† | 0.49 | 0.30 | 0.65 | 0.66 | |||
Abbreviations: CI, confidence interval; HR, hazard risk.
*
The multivariable Cox regression model initially included age, sex, year of diagnosis, family history of colorectal carcinoma in any parent or sibling, tumour location, disease stage, microsatellite instability, CpG island methylator phenotype, KRAS, BRAF, and PIK3CA mutations, and LINE-1 methylation level. A backward stepwise elimination with a threshold of P=0.05 was used to select variables in the final models.
†
Ptrend value was calculated across the ordinal categories of tumour CD274 expression score as a continuous variable in the Cox regression model.