Table 3.
Ingenuity Pathway Analysis of proteins deemed significant at an FDR of 15%
| Top Diseases and Bio Functions | ||
| Diseases and Disorders | ||
| Name | p-value | #Molecules |
| Metabolic Disease | 4.51E-03 – 6.54E-14 | 72 |
| Organismal Injury and Abnormalities | 5.73E-03 – 6.54E-14 | 690 |
| Renal and Urological Disease | 4.51E-03 – 6.54E-14 | 169 |
| Developmental Disorder | 5.03E-03 – 3.97E-13 | 143 |
| Hereditary Disorder | 5.03E-03 – 3.97E-13 | 79 |
| Molecular and Cellular Functions | ||
| Cellular Assembly and Organization | 5.68E-03 – 1.12E-13 | 235 |
| Cellular Function and Maintenance | 5.68E-03 – 1.12E-13 | 201 |
| Cell Death and Survival | 4.51E-03 – 4.48E-09 | 253 |
| Cellular Growth and Proliferation | 5.68E-03 – 9.52E-09 | 278 |
| Cellular Movement | 5.73E-03 – 2.29E-07 | 160 |
| Physiological System Development and Function | ||
| Organismal Survival | 8.66E-11 – 8.66E-11 | 198 |
| Embryonic Development | 5.73E-03 – 1.48E-08 | 130 |
| Tissue Morphology | 4.67E-03 – 1.20E-06 | 95 |
| Organismal Development | 5.73E-03 – 1.20E-05 | 213 |
| Hair and Skin Development and Function | 5.49E-03 – 1.98E-05 | 35 |
| Top Networks | |
| Associated Network Functions | Score |
| Gene Expression, Protein Synthesis, Hematological Disease | 50 |
| Post-Translational Modification, Protein Folding, Cellular Movement | 45 |
| Cellular Assembly and Organization, DNA Replication, Recombination, and Repair, Cellular Compromise | 41 |
| Molecular Transport, Protein Trafficking, Cellular Assembly and Organization | 40 |
| Cardiovascular Disease, Organismal Injury and Abnormalities, Carbohydrate Metabolism | 40 |
| Top Tox Lists | ||
| Name | p-value | Overlap |
| Fatty Acid Metabolism | 3.38E-12 | 21.4 % 25/117 |
| Mitochondrial Dysfunction | 2.06E-04 | 10.2 % 18/176 |
| Increases Renal Proliferation | 2.27E-03 | 9.8 % 13/133 |
| Renal Necrosis/Cell Death | 2.13E-02 | 5.9 % 29/494 |
| Cholesterol Biosynthesis | 2.31E-02 | 18.8 % 3/16 |