Fig. 7.

LLM administration retards orthotopic tumor growth of SUM159 xenograft. A Average body weights over time for mice of control and LLM treatment groups. The results shown are mean ± SD [n = 5 for both groups except at week 7 where n = 3 for control group because two mice from this group were sacrificed one week prior to study termination due to morbidity]. Initial body weight of control group of mice was significantly lower than that of LLM-treated mice by unpaired Student’s t test (P < 0.05). B Total wet tumor weight. Results shown are mean ± SD. C Orthotopic mammary tumor burden in control and LLM-treated mice. Results shown are mean ± SD. * Statistically significant by unpaired Student’s t test. D Representative H&E-stained sections from control and LLM treatment groups (200× magnification; scale bar = 100 μm).