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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: J Periodontal Res. 2016 May 5;52(2):246–254. doi: 10.1111/jre.12388

Fig. 4. A–D: Relative effect of resolvin E1 (RvE1) on P. gingivalis–induced neutrophil cytokine and chemokine responses.

Fig. 4

5×105 neutrophils from either healthy controls (n=10) (○) or subjects with localized aggressive periodontitis (LAgP) (n=10) (■), suspended in RPMI-medium containing 20% (v/v) AB serum were stimulated with 1×107 P. gingivalis for 1 hour at 37°C in presence of 3.6×107 autologous red blood cells (RBCs). Half of the cultures received RvE1 (final concentration: 10nM). Culture supernatants were assessed for content of A) TNF-α, B) IL-6, C) CCL2 and D) CXCL8. The data points represents mean ± 95% confidence intervals of the cytokine levels observed in presence of RvE1 normalized to those observed in absence of RvE1 (=100%). No statistically significant differences (p-values >0.05) from 100% were observed.