Table 4.
Factors associated with day-60 mortality in univariable and multivariable Cox models
| Variables | Univariable analysis | Multivariable analysisa | ||
|---|---|---|---|---|
| HR (95 % CI) | P | HR (95 % CI) | P | |
| Categorization of shock | ||||
| EC-SS | 1 | - | - | |
| Non EC-SS | 0.87 (0.65–1.16) | 0.34 | ||
| Cirrhosis | ||||
| No | 1 | 1 | ||
| Yes | 2.04 (1.42–2.93) | <0.0001 | 2.45 (1.63–3.69) | <0.0001 |
| Cancer | ||||
| No | 1 | 1 | ||
| Yes | 1.62 (1.15–2.28) | 0.006 | 1.91 (1.32–2.75) | <0.001 |
| Chronic respiratory failure | ||||
| No | 1 | 1 | ||
| Yes | 2.16 (1.30–3.59) | 0.003 | 2.45 (1.41–4.26) | 0.002 |
| Age >68 years | ||||
| No | 1 | 1 | ||
| Yes | 1.47 (1.14–1.91) | <0.0001 | 1.73 (1.30–2.30) | <0.0001 |
| SAPS2 > 58 | ||||
| No | 1 | 1 | ||
| Yes | 3.01 (2.28–3.96) | <0.0001 | 1.94 (1.43–2.64) | <0.0001 |
| PT ratio <50% | ||||
| No | 1 | 1 | ||
| Yes | 1.96 (1.50–2.55) | <0.0001 | 1.41 (1.05–1.91) | 0.024 |
| Mechanical ventilation | ||||
| No | 1 | 1 | ||
| Yes | 3.65 (2.33–5.72) | <0.0001 | 2.53 (1.57–4.09) | <0.0001 |
| Lactate, per point in mmol/L | 1.09 (1.07–1.11) | <0.0001 | 1.06 (1.04–1.09) | <0.0001 |
Patients were categorized as having early-confirmed (i.e., within 24 h of vasopressor initiation) septic shock (EC-SS) or not (non EC-SS). aAdjusted for center. CI confidence interval, HR hazard ratio, PT prothrombin time, SAPS2 simplified acute physiology score 2