We calculated the mean (S.E.) annual cortical thickness change using baseline and follow-up cortical thickness MRI measurements in semantic variant primary progressive aphasia. The mean annual cortical thickness is measured within regions where patients displayed cortical baseline thinning, hypoperfusion partially overlapping thinning, hypoperfusion distant from thinning, hyperperfusion partially overlapping thinning, and hyperperfusion distant from thinning. Patients showed significant progressive thinning in regions of baseline thinning, regions of hypoperfusion near thinning, and hyperperfusion near regions of thinning (p<0.05 using paired-sampled t-tests, represented by *). Patients did not show progressive thinning in regions distant from thinning at baseline.