Table 4. Uni/Multivariate analyses.
| UNIVARIATE (Kaplan Meier and Logrank Test) | MULTIVARIATE (Cox Proportional Hazards Model)** | |||||
|---|---|---|---|---|---|---|
| Predictor | Category | Hazard Ratio (CI) | P-Value | Adjusted P Value* | Hazard Ratio (CI) | P-value |
| Age | ≥65 | 0.73 (0.58 – 0.92) | 0.0089 | 0.15 | 0.85 (0.67 – 1.09) | 0.208 |
| <65 | 1.00 | 1.00 | ||||
| Gender | F | 0.89 (0.68 – 1.16) | 0.39 | |||
| M | 1.00 | |||||
| ECOG | 0 | 0.23 (0.15 – 0.34) | <0.0001 | 0.0017 | 0.56 (0.34 – 0.93) | 0.027 |
| 1 | 0.45 (0.30 – 0.68) | 0.0002 | 0.0034 | 0.72 (0.46 – 1.51) | 0.174 | |
| 2 | 1.00 | 1.00 | ||||
| Symptomatic Disease | No | 0.61 (0.47 – 0.80) | 0.0004 | 0.0068 | 1.10 (0.80 – 1.51) | 0.552 |
| Yes | 1.00 | 1.00 | ||||
| Tumor Burden | >0-25% | 0.35 (0.22 – 0.56) | <0.0001 | 0.0017 | 0.68 (0.38 – 1.22) | 0.198 |
| 26-50% | 0.75 (0.45 – 1.25) | 0.277 | 0.79 (0.46 – 1.36) | 0.409 | ||
| >50% | 1.00 | 1.00 | ||||
| Tumor Distribution | Unilobar | 0.56 (0.44 – 0.71) | <0.0001 | 0.0017 | 0.82 (0.60 – 1.11) | 0.202 |
| Bilobar | 1.00 | 1.00 | ||||
| Tumor Size | ≤5 cm | 0.43 (0.32 – 0.60) | <0.0001 | 0.0017 | 0.94 (0.60 – 1.47) | 0.797 |
| >5-10 cm | 0.72 (0.53 – 0.97) | 0.035 | 0.59 | 1.06 (0.72 – 1.55) | 0.754 | |
| >10 cm | 1.00 | 1.00 | ||||
| Number of Lesions | Solitary | 0.48 (0.36 – 0.62) | <0.0001 | 0.0017 | 0.77 (0.54 – 1.10) | 0.162 |
| Multifocal | 1.00 | 1.00 | ||||
| Extrahepatic Metastases | Absent | 0.41 (0.30 – 0.56) | <0.001 | 0.0017 | 0.74 (0.52 – 1.06) | 0.101 |
| Present | 1.00 | 1.00 | ||||
| Infiltrative Tumor | No | 0.29 (0.22 – 0.37) | <0.0001 | 0.0017 | 0.62 (0.44 – 0.89) | 0.008 |
| Yes | 1.00 | 1.00 | ||||
| Portal Venous Thrombosis | Absent | 0.25 (0.19 – 0.33) | <0.0001 | 0.0017 | 0.60 (0.40 – 0.89) | 0.012 |
| Branch | 0.46 (0.33 – 0.65) | <0.0001 | 0.0017 | 0.76 (0.51 – 1.13) | 0.178 | |
| Main | 1.00 | 1.00 | ||||
| Ascites | Absent | 0.35 (0.26 – 46) | <0.0001 | 0.0017 | 0.56 (0.40 – 0.76) | 0.0003 |
| Present | 1.00 | 1.00 | ||||
| Portal Hypertension | Absent | 0.81 (0.63 – 1.05) | 0.120 | 0.78 (0.57 – 1.05) | 0.101 | |
| Present | 1.00 | 1.00 | ||||
| Albumin (g/dL) | ≥ 2.8 | 0.54 (0.43 – 0.69) | <0.0001 | 0.0017 | 0.72 (0.55 – 0.94) | 0.016 |
| < 2.8 | 1.00 | 1.00 | ||||
| Bilirubin (mg/dL) | < 2 | 0.76 (0.55 – 1.05) | 0.1004 | 1.12 (0.78 – 1.61) | 0.512 | |
| ≥ 2 | 1.00 | 1.00 | ||||
| Alkaline Phosphatase (U/L) | ≤ 200 | 0.43 (0.33 – 0.57) | <0.0001 | 0.0017 | 0.68 (0.50 – 0.92) | 0.013 |
| >200 | 1.00 | 1.00 | ||||
| AFP (ng/mL) | ≤200 | 0.54 (0.42 – 0.68) | <0.0001 | 0.0017 | 0.67 (0.51 – 0.86) | 0.002 |
| >200 | 1.00 | 1.00 | ||||
Abbreviations: AFP: Alpha-fetoprotein; CI, confidence interval; ECOG: Eastern Cooperative Oncology Group; HR, hazard ratio
*
Adjusted for multiple comparisons using Bonferroni methodology (correction factor n=17)
**
Factors were included in multivariate analysis if P < 0.15 in univariate analysis (unadjusted for multiple comparisons).