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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Exp Eye Res. 2016 Sep 4;152:10–33. doi: 10.1016/j.exer.2016.08.020

Table 1.

Dexamethasone regulation of genes associated in cell movement

Up regulated genes
Number Symbol Entrez Gene Name Fold
Change
1 PDE2A phosphodiesterase 2A 9.80859
2 TSC22D3 TSC22 domain family member 3 8.37242
3 ALOX5AP arachidonate 5-lipoxygenase-activating protein 5.66178
4 FAM65B family with sequence similarity 65 member B 4.66935
5 PER1 period circadian clock 1 4.65227
6 KLF6 Kruppel-like factor 6 4.38594
7 MMP7 matrix metallopeptidase 7 4.25261
8 ERBB4 erb-b2 receptor tyrosine kinase 4 3.90165
9 EDN2 endothelin 2 3.82819
10 PRKG1 protein kinase, cGMP-dependent, type I 3.7749
11 CGA glycoprotein hormones, alpha polypeptide 3.76295
12 DMBT1 deleted in malignant brain tumors 1 3.72217
13 PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase
and cyclooxygenase)
3.6601
14 FGF8 fibroblast growth factor 8 3.36341
15 PLAT plasminogen activator, tissue type 3.26515
16 TREM1 triggering receptor expressed on myeloid cells 1 3.25299
17 FAM43A family with sequence similarity 43 member A 3.07726
18 TLR2 toll-like receptor 2 3.05242
19 COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2.91731
20 ACKR3 atypical chemokine receptor 3 2.91065
21 CCBE1 collagen and calcium binding EGF domains 1 2.89472
22 IGK immunoglobulin kappa locus 2.77607
23 GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2.72011
24 FFAR4 free fatty acid receptor 4 2.71943
25 BMP7 bone morphogenetic protein 7 2.63977
26 SCNN1A sodium channel, non voltage gated 1 alpha subunit 2.601
27 MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 2.59413
28 C2 complement component 2 2.56885
29 RGCC regulator of cell cycle 2.5588
30 ZAP70 zeta chain of T cell receptor associated protein kinase 70kDa 2.52303
31 PDIA2 protein disulfide isomerase family A member 2 2.52092
32 PTGES prostaglandin E synthase 2.49236
33 G6PC glucose-6-phosphatase, catalytic subunit 2.47483
34 WNT11 wingless-type MMTV integration site family member 11 2.45361
35 ERRFI1 ERBB receptor feedback inhibitor 1 2.42978
36 LMO7 LIM domain 7 2.42814
37 TWIST1 twist family bHLH transcription factor 1 2.39978
38 SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 5
2.39942
39 EDNRB endothelin receptor type B 2.39193
40 GP1BA glycoprotein Ib platelet alpha subunit 2.38223
41 SFRP5 secreted frizzled-related protein 5 2.3733
42 KCNH2 potassium channel, voltage gated eag related subfamily H, member
2
2.33941
43 ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 2.31557
44 PTGER2 prostaglandin E receptor 2 2.3143
45 TDGF1 teratocarcinoma-derived growth factor 1 2.31039
46 TREM2 triggering receptor expressed on myeloid cells 2 2.30895
47 BARX2 BARX homeobox 2 2.29272
48 TNS4 tensin 4 2.2516
49 SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.24862
50 SOX10 SRY-box 10 2.23462
51 NME8 NME/NM23 family member 8 2.22648
52 HYAL1 hyaluronoglucosaminidase 1 2.22431
53 SFRP2 secreted frizzled-related protein 2 2.22094
54 ANXA2 annexin A2 2.21004
55 CSF1R colony stimulating factor 1 receptor 2.20717
56 MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma
derived homolog
2.18662
57 PNOC prepronociceptin 2.18369
58 POU3F2 POU class 3 homeobox 2 2.14487
59 LHX6 LIM homeobox 6 2.13937
60 NCAM1 neural cell adhesion molecule 1 2.12964
61 UNC5C unc-5 netrin receptor C 2.12805
62 SAA1 serum amyloid A1 2.12535
63 ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 2.12256
64 SEPT4 septin 4 2.09427
65 SEMA6D semaphorin 6D 2.08409
66 AHSG alpha-2-HS-glycoprotein 2.04678
67 FOXO4 forkhead box O4 2.03975
68 DUSP1 dual specificity phosphatase 1 2.03074
69 PIGR polymeric immunoglobulin receptor 2.02612
70 CSPG4 chondroitin sulfate proteoglycan 4 2.02415
71 SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 3
2.02111
72 FGD4 FYVE, RhoGEF and PH domain containing 4 2.01625
73 DACT2 dishevelled-binding antagonist of beta-catenin 2 1.99964
74 OVOL2 ovo-like zinc finger 2 1.99502
75 HTRA3 HtrA serine peptidase 3 1.98175
76 LOX lysyl oxidase 1.96085
77 SNAI2 snail family zinc finger 2 1.95867
78 ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 1.95677
79 DKK1 dickkopf WNT signaling pathway inhibitor 1 1.95068
80 CAV3 caveolin 3 1.93759
81 PDPK1 3-phosphoinositide dependent protein kinase 1 1.93146
82 SGK1 serum/glucocorticoid regulated kinase 1 1.92796
83 CX3CL1 chemokine (C-X3-C motif) ligand 1 1.90246
84 RECK reversion-inducing-cysteine-rich protein with kazal motifs 1.90193
85 TAF7L TATA-box binding protein associated factor 7 like 1.89943
86 CXCL9 chemokine (C-X-C motif) ligand 9 1.89439
87 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator
inhibitor type 1), member 1
1.89231
88 ESAM endothelial cell adhesion molecule 1.8895
89 MUC2 mucin 2, oligomeric mucus/gel-forming 1.88395
90 CCKBR cholecystokinin B receptor 1.88322
91 MTSS1 metastasis suppressor 1 1.87278
92 SRCIN1 SRC kinase signaling inhibitor 1 1.87237
93 SCNN1G sodium channel, non voltage gated 1 gamma subunit 1.87131
94 GUCY1A3 guanylate cyclase 1, soluble, alpha 3 1.86393
95 BCAN brevican 1.84483
96 MMP28 matrix metallopeptidase 28 1.84228
97 A4GALT alpha 1,4-galactosyltransferase 1.83856
98 ARRDC3 arrestin domain containing 3 1.82678
99 IL17C interleukin 17C 1.80878
100 TNFRSF18 tumor necrosis factor receptor superfamily member 18 1.80542
101 LMCD1 LIM and cysteine-rich domains 1 1.79297
102 APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 1.78296
103 GPR173 G protein-coupled receptor 173 1.76787
104 CD22 CD22 molecule 1.7662
105 ARID5B AT-rich interaction domain 5B 1.76014
106 COL2A1 collagen, type II, alpha 1 1.73823
107 TREML2 triggering receptor expressed on myeloid cells like 2 1.72252
108 CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 1.71418
109 DMD dystrophin 1.70442
110 PTGDR2 prostaglandin D2 receptor 2 1.6963
111 CSF1 colony stimulating factor 1 1.69629
112 DEFB1 defensin beta 1 1.69534
113 AHNAK AHNAK nucleoprotein 1.69458
114 ALPPL2 alkaline phosphatase, placental like 2 1.69249
115 ITGB6 integrin subunit beta 6 1.69233
116 KDR kinase insert domain receptor 1.69116
117 NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells
inhibitor, alpha
1.68325
118 THBD thrombomodulin 1.68252
119 DSG3 desmoglein 3 1.68104
120 IL6R interleukin 6 receptor 1.67241
121 AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.67019
122 CKLF chemokine-like factor 1.6601
123 FABP5 fatty acid binding protein 5 (psoriasis-associated) 1.65888
124 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 1.65114
125 STAB2 stabilin 2 1.64157
126 GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.64096
127 STAB1 stabilin 1 1.6352
128 HOXC9 homeobox C9 1.63051
129 KRT6B keratin 6B, type II 1.61929
130 IL6ST interleukin 6 signal transducer 1.61917
131 GGT5 gamma-glutamyltransferase 5 1.61518
132 PTH1R parathyroid hormone 1 receptor 1.61329
133 FOXO1 forkhead box O1 1.6106
134 OPRD1 opioid receptor, delta 1 1.61012
135 TNFSF8 tumor necrosis factor superfamily member 8 1.60148
136 TG thyroglobulin 1.59772
137 GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.59632
138 MYO9A myosin IXA 1.58634
139 TXNDC2 thioredoxin domain containing 2 (spermatozoa) 1.57836
140 WNT5A wingless-type MMTV integration site family member 5A 1.56678
141 ROR1 receptor tyrosine kinase-like orphan receptor 1 1.56674
142 CRMP1 collapsin response mediator protein 1 1.55331
143 ATF3 activating transcription factor 3 1.55296
144 NTF4 neurotrophin 4 1.54373
145 C5AR2 complement component 5a receptor 2 1.54316
146 CD209 CD209 molecule 1.54084
147 TGFBR2 transforming growth factor beta receptor II 1.53985
148 HLA-G major histocompatibility complex, class I, G 1.53451
149 CDH4 cadherin 4 1.5343
150 SPARCL1 SPARC like 1 1.53001
151 SFTPA1 surfactant protein A1 1.52362
152 FAP fibroblast activation protein alpha 1.51341
153 MUC1 mucin 1, cell surface associated 1.50915
154 HIPK2 homeodomain interacting protein kinase 2 1.50556
155 LAMA3 laminin subunit alpha 3 1.50543
156 ADGRL3 adhesion G protein-coupled receptor L3 1.50267
157 NDRG1 N-myc downstream regulated 1 1.5009
158 DNAH11 dynein, axonemal, heavy chain 11 1.49615
159 HTRA1 HtrA serine peptidase 1 1.49229
160 DKK3 dickkopf WNT signaling pathway inhibitor 3 1.48976
161 IRX2 iroquois homeobox 2 1.48728
162 AKAP12 A-kinase anchoring protein 12 1.48594
163 CD8A CD8a molecule 1.48588
164 CTGF connective tissue growth factor 1.47837
165 PROK1 prokineticin 1 1.47053
166 MAVS mitochondrial antiviral signaling protein 1.46925
167 IRS2 insulin receptor substrate 2 1.46551
168 ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 1.46535
169 SEMA5A semaphorin 5A 1.46424
170 AFAP1L1 actin filament associated protein 1 like 1 1.46064
171 MAPT microtubule associated protein tau 1.45851
172 FOSL2 FOS like antigen 2 1.45689
173 NFIA nuclear factor I/A 1.45523
174 EGFR epidermal growth factor receptor 1.44947
175 ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 1.4478
176 ALPP alkaline phosphatase, placental 1.44571
177 TUBB2B tubulin beta 2B class IIb 1.4385
178 NTN1 netrin 1 1.43575
179 CXCL5 chemokine (C-X-C motif) ligand 5 1.43458
180 CRYAB crystallin alpha B 1.43261
181 PLD1 phospholipase D1 1.42163
182 CD59 CD59 molecule 1.42106
183 KLF4 Kruppel-like factor 4 (gut) 1.41722
184 VNN2 vanin 2 1.41559
185 PLXNA2 plexin A2 1.40612
186 CMA1 chymase 1, mast cell 1.40552
187 SLC30A4 solute carrier family 30 (zinc transporter), member 4 1.40175
188 UNC5B unc-5 netrin receptor B 1.39967
189 MARVELD MARVEL domain containing 3 1.3954
190 ABLIM1 actin binding LIM protein 1 1.39124
191 FBLIM1 filamin binding LIM protein 1 1.39083
192 JUNB jun B proto-oncogene 1.38982
193 KLF8 Kruppel-like factor 8 1.38587
194 CHRNA7 cholinergic receptor, nicotinic alpha 7 1.38155
195 ITGB7 integrin subunit beta 7 1.37875
196 ROBO3 roundabout guidance receptor 3 1.37754
197 PXN paxillin 1.37578
198 CTSC cathepsin C 1.37552
199 FLNB filamin B 1.37067
200 CAMK2G calcium/calmodulin-dependent protein kinase II gamma 1.36898
201 GPC1 glypican 1 1.36368
202 TRIP10 thyroid hormone receptor interactor 10 1.36183
203 GLI3 GLI family zinc finger 3 1.35695
204 PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.35597
205 TSC1 tuberous sclerosis 1 1.35562
206 IL15 interleukin 15 1.35092
207 TNFRSF1A tumor necrosis factor receptor superfamily member 1A 1.34708
208 GLI2 GLI family zinc finger 2 1.34616
209 DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.3451
210 CEBPD CCAAT/enhancer binding protein delta 1.34448
211 NOD1 nucleotide binding oligomerization domain containing 1 1.34023
212 RHOB ras homolog family member B 1.33951
213 PDLIM1 PDZ and LIM domain 1 1.33705
214 ALOX15 arachidonate 15-lipoxygenase 1.33616
215 GPR161 G protein-coupled receptor 161 1.33444
216 CRIP2 cysteine-rich protein 2 1.32923
217 ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 1.32742
218 CEBPE CCAAT/enhancer binding protein epsilon 1.32704
219 ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 1.31809
220 SIRPA signal-regulatory protein alpha 1.3081
221 IFNGR1 interferon gamma receptor 1 1.30326
222 APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 1.29918
223 CREB3L1 cAMP responsive element binding protein 3-like 1 1.29846
224 WASF2 WAS protein family member 2 1.29785
225 KRT16 keratin 16, type I 1.29531
226 ANO6 anoctamin 6 1.29504
227 FPR1 formyl peptide receptor 1 1.2919
228 GBA glucosidase, beta, acid 1.28636
229 NEURL1 neuralized E3 ubiquitin protein ligase 1 1.28481
230 EFNB1 ephrin-B1 1.28338
231 REPS2 RALBP1 associated Eps domain containing 2 1.28076
232 CAV1 caveolin 1 1.27821
233 FHOD1 formin homology 2 domain containing 1 1.2777
234 TBXAS1 thromboxane A synthase 1 1.27669
235 ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.27432
236 KLK7 kallikrein related peptidase 7 1.27282
237 CTSB cathepsin B 1.2722
238 E2F2 E2F transcription factor 2 1.26991
239 ATF2 activating transcription factor 2 1.26929
240 ANG angiogenin, ribonuclease, RNase A family, 5 1.26295
241 FOXQ1 forkhead box Q1 1.26212
242 IGFBP3 insulin like growth factor binding protein 3 1.24814
243 KLF5 Kruppel-like factor 5 (intestinal) 1.24315
244 PEX11B peroxisomal biogenesis factor 11 beta 1.24302
245 CTBP2 C-terminal binding protein 2 1.23906
246 GADD45A growth arrest and DNA damage inducible alpha 1.23381
247 UNK unkempt family zinc finger 1.22682
248 EPHB2 EPH receptor B2 1.22406
249 SEPT11 septin 11 1.21872
250 FLCN folliculin 1.21512
251 LIMK2 LIM domain kinase 2 1.2114
252 ALOX5 arachidonate 5-lipoxygenase 1.21048
253 STARD13 StAR related lipid transfer domain containing 13 1.20956
254 KIF1C kinesin family member 1C 1.20914
255 CEBPB CCAAT/enhancer binding protein beta 1.20899
256 CFB complement factor B 1.20881
257 PRKCZ protein kinase C, zeta 1.20575
258 PML promyelocytic leukemia 1.20095
259 WASF1 WAS protein family member 1 1.19908
260 MYO1E myosin IE 1.19684
261 PPARA peroxisome proliferator-activated receptor alpha 1.1953
262 MFI2 antigen p97 (melanoma associated) identified by monoclonal
antibodies 133.2 and 96.5
1.19307
263 THRA thyroid hormone receptor, alpha 1.19212
264 PLCG2 phospholipase C gamma 2 1.19
265 NOL3 nucleolar protein 3 1.18725
266 DCTN2 dynactin subunit 2 1.18711
267 SWAP70 SWAP switching B-cell complex 70kDa subunit 1.18608
268 TYRO3 TYRO3 protein tyrosine kinase 1.18563
269 OGG1 8-oxoguanine DNA glycosylase 1.18292
270 DOK1 docking protein 1 1.17558
271 LIMS2 LIM-type zinc finger domains 2 1.16949
272 GRHL2 grainyhead like transcription factor 2 1.16062
273 CDC42BPB CDC42 binding protein kinase beta 1.16052
274 CDK5RAP3 CDK5 regulatory subunit associated protein 3 1.15733
275 ROBO4 roundabout guidance receptor 4 1.15231
276 MAPK7 mitogen-activated protein kinase 7 1.14122
277 NISCH nischarin 1.1397
278 TXN thioredoxin 1.13966
279 BATF3 basic leucine zipper transcription factor, ATF-like 3 1.1359
280 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 1.13579
281 RRAS related RAS viral (r-ras) oncogene homolog 1.10437
282 LPAR4 lysophosphatidic acid receptor 4 1.0704
283 LILRB1 leukocyte immunoglobulin like receptor B1 1.06714
284 GPR18 G protein-coupled receptor 18 1.06277
285 SELP selectin P 1.06242
286 SH2D3C SH2 domain containing 3C 1.06103
287 IL16 interleukin 16 1.05912
288 ESR1 estrogen receptor 1 1.05874
289 PLXNC1 plexin C1 1.05869
290 BCL11B B-cell CLL/lymphoma 11B 1.05823
291 CYP19A1 cytochrome P450 family 19 subfamily A member 1 1.05594
292 CCR8 chemokine (C-C motif) receptor 8 1.05587
293 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 1.05141
294 RARRES2 retinoic acid receptor responder (tazarotene induced) 2 1.04311
Down regulated genes
Number Symbol Entrez Gene Name Fold
Change
1 PHLDA1 pleckstrin homology-like domain, family A, member 1 −8.46535
2 TNFRSF11B tumor necrosis factor receptor superfamily member 11b −7.88483
3 PDE4B phosphodiesterase 4B −5.22171
4 IL6 interleukin 6 −4.46666
5 FGF5 fibroblast growth factor 5 −4.31595
6 CD36 CD36 molecule −3.92846
7 IL1B interleukin 1 beta −3.74371
8 EREG epiregulin −3.51023
9 CCL2 chemokine (C-C motif) ligand 2 −3.41548
10 RUNX2 runt-related transcription factor 2 −2.95184
11 IGFBP5 insulin like growth factor binding protein 5 −2.92668
12 CXCL8 chemokine (C-X-C motif) ligand 8 −2.91859
13 CYP26A1 cytochrome P450 family 26 subfamily A member 1 −2.91556
14 PLAU plasminogen activator, urokinase −2.90533
15 IL24 interleukin 24 −2.88468
16 ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 −2.88077
17 SEMA3A semaphorin 3A −2.87725
18 TNFSF15 tumor necrosis factor superfamily member 15 −2.81580
19 FGFR1 fibroblast growth factor receptor 1 −2.76805
20 DIO2 deiodinase, iodothyronine, type II −2.73236
21 TXK TXK tyrosine kinase −2.62840
22 SEMA3D semaphorin 3D −2.58360
23 FGFBP1 fibroblast growth factor binding protein 1 −2.51183
24 KCNA3 potassium channel, voltage gated shaker related subfamily A,
member 3
−2.50982
25 FAT3 FAT atypical cadherin 3 −2.46791
26 CCRL2 chemokine (C-C motif) receptor-like 2 −2.45201
27 NPPB natriuretic peptide B −2.41923
28 ETV1 ets variant 1 −2.41900
29 LIF leukemia inhibitory factor −2.41840
30 CD28 CD28 molecule −2.40401
31 EHF ets homologous factor −2.39617
32 SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 −2.37556
33 SEMA3E semaphorin 3E −2.35253
34 CSF2 colony stimulating factor 2 −2.34563
35 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 −2.32584
36 CEMIP cell migration inducing protein, hyaluronan binding −2.29345
37 FOSL1 FOS like antigen 1 −2.28415
38 TFPI2 tissue factor pathway inhibitor 2 −2.26858
39 BDNF brain-derived neurotrophic factor −2.24540
40 NR0B1 nuclear receptor subfamily 0 group B member 1 −2.23654
41 OPRM1 opioid receptor, mu 1 −2.23159
42 CCL3 chemokine (C-C motif) ligand 3 −2.22620
43 CYP1B1 cytochrome P450 family 1 subfamily B member 1 −2.20031
44 SCRN3 secernin 3 −2.13833
45 CSH1/CSH2 chorionic somatomammotropin hormone 1 −2.12536
46 SPRY4 sprouty RTK signaling antagonist 4 −2.12339
47 RGS4 regulator of G-protein signaling 4 −2.08806
48 NR2F1 nuclear receptor subfamily 2 group F member 1 −2.08334
49 IL23A interleukin 23 subunit alpha −2.08326
50 IFIT2 interferon induced protein with tetratricopeptide repeats 2 −2.07608
51 FOXA1 forkhead box A1 −2.06692
52 F3 coagulation factor III, tissue factor −2.05004
53 ITGA2 integrin subunit alpha 2 −2.04652
54 CCDC40 coiled-coil domain containing 40 −2.04553
55 ZBTB18 zinc finger and BTB domain containing 18 −2.03725
56 GDNF glial cell derived neurotrophic factor −2.02472
57 CLDN11 claudin 11 −2.02083
58 IER3 immediate early response 3 −1.97907
59 NOG noggin −1.97215
60 BDKRB2 bradykinin receptor B2 −1.96909
61 CLDN1 claudin 1 −1.95484
62 GREM1 gremlin 1, DAN family BMP antagonist −1.95480
63 CCL3L3 chemokine (C-C motif) ligand 3-like 3 −1.94494
64 ADAM19 ADAM metallopeptidase domain 19 −1.93804
65 ETV5 ets variant 5 −1.93529
66 STC1 stanniocalcin 1 −1.92768
67 CDH11 cadherin 11 −1.92589
68 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating
activity, alpha)
−1.92384
69 CADM1 cell adhesion molecule 1 −1.92359
70 TNFRSF21 tumor necrosis factor receptor superfamily member 21 −1.91959
71 E2F5 E2F transcription factor 5, p130-binding −1.91884
72 CD44 CD44 molecule (Indian blood group) −1.91830
73 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 −1.89520
74 SMAD3 SMAD family member 3 −1.86856
75 ADAM8 ADAM metallopeptidase domain 8 −1.86707
76 HBEGF heparin-binding EGF-like growth factor −1.85743
77 SOX9 SRY-box 9 −1.84049
78 NOV nephroblastoma overexpressed −1.83286
79 IRF8 interferon regulatory factor 8 −1.83215
80 GDF15 growth differentiation factor 15 −1.82966
81 HAVCR2 hepatitis A virus cellular receptor 2 −1.82840
82 LIPE lipase, hormone-sensitive −1.82349
83 SHC4 SHC (Src homology 2 domain containing) family member 4 −1.82181
84 ITGB8 integrin subunit beta 8 −1.81877
85 PRKCE protein kinase C, epsilon −1.81237
86 PTHLH parathyroid hormone-like hormone −1.79945
87 SPRY2 sprouty RTK signaling antagonist 2 −1.77757
88 PHLDA2 pleckstrin homology-like domain, family A, member 2 −1.76688
89 F2RL1 coagulation factor II (thrombin) receptor-like 1 −1.75500
90 HDAC9 histone deacetylase 9 −1.75136
91 CAMK2D calcium/calmodulin-dependent protein kinase II delta −1.74928
92 VEGFA vascular endothelial growth factor A −1.74782
93 IL21R interleukin 21 receptor −1.74709
94 MAP2K6 mitogen-activated protein kinase kinase 6 −1.74136
95 GPER1 G protein-coupled estrogen receptor 1 −1.73288
96 ADRA2A adrenoceptor alpha 2A −1.72940
97 CCND1 cyclin D1 −1.72596
98 CDCP1 CUB domain containing protein 1 −1.72023
99 CD274 CD274 molecule −1.70099
100 WNT7B wingless-type MMTV integration site family member 7B −1.69513
101 MMP13 matrix metallopeptidase 13 −1.69399
102 WNT7A wingless-type MMTV integration site family member 7A −1.69365
103 SOX7 SRY-box 7 −1.68947
104 AQP3 aquaporin 3 (Gill blood group) −1.68904
105 NGF nerve growth factor (beta polypeptide) −1.68514
106 VEGFC vascular endothelial growth factor C −1.67461
107 CFTR cystic fibrosis transmembrane conductance regulator −1.67311
108 CEACAM1 carcinoembryonic antigen related cell adhesion molecule 1 −1.67013
109 BCL3 B-cell CLL/lymphoma 3 −1.66934
110 EGF epidermal growth factor −1.66451
111 NUAK1 NUAK family, SNF1-like kinase, 1 −1.66163
112 MAP2K3 mitogen-activated protein kinase kinase 3 −1.65913
113 NUAK2 NUAK family, SNF1-like kinase, 2 −1.65090
114 PTX3 pentraxin 3 −1.65079
115 IL11 interleukin 11 −1.64764
116 TFAP2A transcription factor AP-2 alpha (activating enhancer binding
protein 2 alpha)
−1.64024
117 DUSP6 dual specificity phosphatase 6 −1.63858
118 EPAS1 endothelial PAS domain protein 1 −1.63589
119 DNMBP dynamin binding protein −1.62689
120 PLAUR plasminogen activator, urokinase receptor −1.62192
121 SLIT2 slit guidance ligand 2 −1.61888
122 AFAP1 actin filament associated protein 1 −1.61378
123 TM4SF1 transmembrane 4 L six family member 1 −1.60547
124 DLC1 DLC1 Rho GTPase activating protein −1.60302
125 DLX2 distal-less homeobox 2 −1.59963
126 IL15RA interleukin 15 receptor subunit alpha −1.59691
127 DUSP4 dual specificity phosphatase 4 −1.59289
128 RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) −1.58550
129 LTB lymphotoxin beta −1.58178
130 CLDN4 claudin 4 −1.57162
131 NR2F2 nuclear receptor subfamily 2 group F member 2 −1.56903
132 OSMR oncostatin M receptor −1.56874
133 LRP8 LDL receptor related protein 8 −1.56623
134 STX6 syntaxin 6 −1.56481
135 ST6GALNAC
5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-
acetylgalactosaminide alpha-2,6-sialyltransferase 5
−1.56360
136 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase −1.56352
137 TCF4 transcription factor 4 −1.55623
138 MYO10 myosin X −1.55431
139 PTAFR platelet-activating factor receptor −1.55164
140 SASH1 SAM and SH3 domain containing 1 −1.54902
141 NRG1 neuregulin 1 −1.54870
142 SFRP4 secreted frizzled-related protein 4 −1.54760
143 OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 −1.54270
144 MMP1 matrix metallopeptidase 1 −1.54030
145 LYN LYN proto-oncogene, Src family tyrosine kinase −1.53885
146 CLDN3 claudin 3 −1.53743
147 SH3KBP1 SH3-domain kinase binding protein 1 −1.53570
148 EGLN3 egl-9 family hypoxia-inducible factor 3 −1.52322
149 PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit
delta
−1.51461
150 BACH2 BTB and CNC homology 1, basic leucine zipper transcription
factor 2
−1.51327
151 FST follistatin −1.50979
152 SOCS3 suppressor of cytokine signaling 3 −1.50825
153 ADORA2B adenosine A2b receptor −1.50713
154 ETV6 ets variant 6 −1.50633
155 S100A7A S100 calcium binding protein A7A −1.50499
156 AMOTL1 angiomotin like 1 −1.49759
157 TMSB10/TM
SB4X
thymosin beta 10 −1.49466
158 P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 −1.49425
159 RARRES1 retinoic acid receptor responder (tazarotene induced) 1 −1.49203
160 CXADR coxsackie virus and adenovirus receptor −1.49154
161 MMP2 matrix metallopeptidase 2 −1.48914
162 CCK cholecystokinin −1.48872
163 ODC1 ornithine decarboxylase 1 −1.48278
164 LDLR low density lipoprotein receptor −1.48242
165 SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter),
member 2
−1.48129
166 SPNS2 spinster homolog 2 (Drosophila) −1.47624
167 EPHB3 EPH receptor B3 −1.47347
168 HSP90AA1 heat shock protein 90kDa alpha family class A member 1 −1.47258
169 BDKRB1 bradykinin receptor B1 −1.46892
170 ITGA6 integrin subunit alpha 6 −1.46736
171 CMTM8 CKLF-like MARVEL transmembrane domain containing 8 −1.46426
172 C5AR1 complement component 5a receptor 1 −1.46246
173 KRAS Kirsten rat sarcoma viral oncogene homolog −1.45816
174 HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-
coupled
−1.45507
175 CIITA class II, major histocompatibility complex, transactivator −1.45446
176 BHLHE41 basic helix-loop-helix family member e41 −1.45152
177 PTK2 protein tyrosine kinase 2 −1.44795
178 FAM60A family with sequence similarity 60 member A −1.44001
179 ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix
protein
−1.43998
180 TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) −1.43844
181 MESP1 mesoderm posterior bHLH transcription factor 1 −1.43834
182 TGFA transforming growth factor alpha −1.4379
183 CNN1 calponin 1, basic, smooth muscle −1.4304
184 TFPI tissue factor pathway inhibitor −1.42959
185 ETV4 ets variant 4 −1.42898
186 HMGA2 high mobility group AT-hook 2 −1.42812
187 PELI1 pellino E3 ubiquitin protein ligase 1 −1.42779
188 LCP2 lymphocyte cytosolic protein 2 −1.42448
189 CTNNA2 catenin alpha 2 −1.42091
190 TYR tyrosinase −1.42076
191 TPM1 tropomyosin 1 (alpha) −1.42072
192 SULT2B1 sulfotransferase family 2B member 1 −1.42007
193 ADAM12 ADAM metallopeptidase domain 12 −1.42003
194 SELL selectin L −1.41915
195 HAS3 hyaluronan synthase 3 −1.41793
196 RIPK2 receptor interacting serine/threonine kinase 2 −1.41689
197 SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 −1.41412
198 AQP1 aquaporin 1 (Colton blood group) −1.4135
199 CATSPERD catsper channel auxiliary subunit delta −1.41101
200 ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 −1.411
201 SCN9A sodium channel, voltage gated, type IX alpha subunit −1.4108
202 SMAD7 SMAD family member 7 −1.40998
203 ICAM1 intercellular adhesion molecule 1 −1.40688
204 HGF hepatocyte growth factor (hepapoietin A; scatter factor) −1.40635
205 IGF1R insulin like growth factor 1 receptor −1.40444
206 SYNM synemin −1.40255
207 PODXL podocalyxin-like −1.40063
208 CLEC7A C-type lectin domain family 7 member A −1.40008
209 STK35 serine/threonine kinase 35 −1.3991
210 ADORA3 adenosine A3 receptor −1.39827
211 NR1D1 nuclear receptor subfamily 1 group D member 1 −1.39569
212 ZDHHC20 zinc finger, DHHC-type containing 20 −1.39423
213 FOXP1 forkhead box P1 −1.39132
214 CAPN12 calpain 12 −1.39041
215 ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide −1.38932
216 CXCL2 chemokine (C-X-C motif) ligand 2 −1.38857
217 JAG1 jagged 1 −1.388
218 RUNX1 runt-related transcription factor 1 −1.38576
219 RASSF5 Ras association (RalGDS/AF-6) domain family member 5 −1.38344
220 MYH11 myosin, heavy chain 11, smooth muscle −1.37585
221 PPIF peptidylprolyl isomerase F −1.37223
222 AJAP1 adherens junctions associated protein 1 −1.37108
223 IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) −1.37108
224 SNAI1 snail family zinc finger 1 −1.36983
225 EIF4E eukaryotic translation initiation factor 4E −1.36964
226 RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 −1.36863
227 PTPRK protein tyrosine phosphatase, receptor type K −1.36543
228 CDC42EP1 CDC42 effector protein 1 −1.36535
229 GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood
group)
−1.36516
230 DEFB103A/D
EFB103B
defensin beta 103B −1.36313
231 VDR vitamin D (1,25- dihydroxyvitamin D3) receptor −1.36297
232 PARD6B par-6 family cell polarity regulator beta −1.36193
233 IER2 immediate early response 2 −1.36131
234 DLL1 delta-like 1 (Drosophila) −1.36055
235 PTPRR protein tyrosine phosphatase, receptor type R −1.35893
236 CATSPER1 cation channel, sperm associated 1 −1.3582
237 WNT4 wingless-type MMTV integration site family member 4 −1.34903
238 PTP4A1 protein tyrosine phosphatase type IVA, member 1 −1.34726
239 TNFRSF10A tumor necrosis factor receptor superfamily member 10a −1.34601
240 EPHB1 EPH receptor B1 −1.34462
241 TNFRSF12A tumor necrosis factor receptor superfamily member 12A −1.34406
242 GEMIN5 gem nuclear organelle associated protein 5 −1.34324
243 LMO4 LIM domain only 4 −1.34176
244 FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) −1.3409
245 MYF5 myogenic factor 5 −1.33933
246 NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit −1.33862
247 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 −1.33628
248 AGTR2 angiotensin II receptor type 2 −1.33574
249 MITF microphthalmia-associated transcription factor −1.33566
250 CHL1 cell adhesion molecule L1-like −1.33449
251 WISP2 WNT1 inducible signaling pathway protein 2 −1.33436
252 TLR3 toll-like receptor 3 −1.33216
253 PRSS27 protease, serine 27 −1.32726
254 FUT3 fucosyltransferase 3 (Lewis blood group) −1.32708
255 GLRX glutaredoxin −1.3242
256 TGFBI transforming growth factor beta induced −1.32276
257 KNG1 kininogen 1 −1.32215
258 ONECUT2 one cut homeobox 2 −1.32092
259 RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 −1.3207
260 TSHR thyroid stimulating hormone receptor −1.32046
261 HSP90AB1 heat shock protein 90kDa alpha family class B member 1 −1.31987
262 GAD1 glutamate decarboxylase 1 −1.31719
263 SPAG9 sperm associated antigen 9 −1.31697
264 FGF2 fibroblast growth factor 2 (basic) −1.31569
265 SOCS4 suppressor of cytokine signaling 4 −1.31507
266 IL17RB interleukin 17 receptor B −1.3143
267 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit
gamma
−1.31388
268 MNX1 motor neuron and pancreas homeobox 1 −1.31094
269 ASPH aspartate beta-hydroxylase −1.31058
270 PDGFB platelet derived growth factor subunit B −1.30629
271 SYNJ2BP synaptojanin 2 binding protein −1.30419
272 VAV1 vav guanine nucleotide exchange factor 1 −1.30245
273 PLPP3 phospholipid phosphatase 3 −1.30085
274 RELB v-rel avian reticuloendotheliosis viral oncogene homolog B −1.29866
275 YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
activation protein, theta
−1.29533
276 NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 −1.28877
277 DYX1C1 dyslexia susceptibility 1 candidate 1 −1.28795
278 CLEC5A C-type lectin domain family 5 member A −1.28692
279 POMK protein-O-mannose kinase −1.28647
280 ZFAND5 zinc finger, AN1-type domain 5 −1.28575
281 SMN1/SMN2 survival of motor neuron 1, telomeric −1.28521
282 EFNA1 ephrin-A1 −1.28027
283 VTCN1 V-set domain containing T cell activation inhibitor 1 −1.27926
284 AMD1 adenosylmethionine decarboxylase 1 −1.27848
285 RND3 Rho family GTPase 3 −1.27788
286 DCBLD2 discoidin, CUB and LCCL domain containing 2 −1.27761
287 GJA1 gap junction protein alpha 1 −1.27588
288 HOXA2 homeobox A2 −1.27472
289 TWIST2 twist family bHLH transcription factor 2 −1.273
290 ADGRG1 adhesion G protein-coupled receptor G1 −1.26945
291 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2
beta
−1.26945
292 NAMPT nicotinamide phosphoribosyltransferase −1.26749
293 PRMT6 protein arginine methyltransferase 6 −1.26295
294 TRAF3 TNF receptor associated factor 3 −1.26024
295 EZR ezrin −1.25889
296 PPP1R15A protein phosphatase 1 regulatory subunit 15A −1.25828
297 DRAM1 DNA damage regulated autophagy modulator 1 −1.25703
298 SNCA synuclein alpha −1.25233
299 OCLN occludin −1.25226
300 KCNK5 potassium channel, two pore domain subfamily K, member 5 −1.25156
301 PRLR prolactin receptor −1.2486
302 BCAR1 breast cancer anti-estrogen resistance 1 −1.24785
303 NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive −1.24658
304 RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP
binding protein Rac2)
−1.24535
305 MALT1 MALT1 paracaspase −1.24468
306 HHEX hematopoietically expressed homeobox −1.24069
307 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 −1.23969
308 NET1 neuroepithelial cell transforming 1 −1.23934
309 TCAF1 TRPM8 channel-associated factor 1 −1.239
310 ARHGAP19 Rho GTPase activating protein 19 −1.23845
311 ZNF652 zinc finger protein 652 −1.23649
312 CCL26 chemokine (C-C motif) ligand 26 −1.23552
313 MIEN1 migration and invasion enhancer 1 −1.2349
314 SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase −1.23249
315 MYO5B myosin VB −1.23164
316 RAG1 recombination activating gene 1 −1.2303
317 CGB3
(includes
others)
chorionic gonadotropin beta subunit 3 −1.22918
318 RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) −1.22615
319 B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide
5
−1.22529
320 GSK3B glycogen synthase kinase 3 beta −1.22451
321 CDK6 cyclin-dependent kinase 6 −1.22402
322 CTNNAL1 catenin alpha-like 1 −1.22048
323 CD58 CD58 molecule −1.21835
324 CYR61 cysteine rich angiogenic inducer 61 −1.21306
325 ZNF24 zinc finger protein 24 −1.21218
326 DGKE diacylglycerol kinase epsilon −1.21008
327 PTEN phosphatase and tensin homolog −1.20912
328 WWC1 WW and C2 domain containing 1 −1.20909
329 SFRP1 secreted frizzled-related protein 1 −1.20491
330 ABHD6 abhydrolase domain containing 6 −1.20477
331 NEU1 neuraminidase 1 (lysosomal sialidase) −1.19821
332 UBE2I ubiquitin conjugating enzyme E2I −1.19721
333 EBI3 Epstein-Barr virus induced 3 −1.19684
334 ZEB2 zinc finger E-box binding homeobox 2 −1.19545
335 MMP16 matrix metallopeptidase 16 −1.19347
336 CD93 CD93 molecule −1.19321
337 ANXA1 annexin A1 −1.19311
338 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II −1.19140
339 ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 −1.19127
340 BBS4 Bardet-Biedl syndrome 4 −1.19104
341 SRPX2 sushi-repeat containing protein, X-linked 2 −1.19022
342 CXCR6 chemokine (C-X-C motif) receptor 6 −1.19013
343 TAC1 tachykinin precursor 1 −1.18419
344 FAM188A family with sequence similarity 188 member A −1.18353
345 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells
1
−1.18152
346 BAG1 BCL2 associated athanogene 1 −1.17465
347 EHD1 EH domain containing 1 −1.17454
348 LIMA1 LIM domain and actin binding 1 −1.17448
349 MOV10L1 Mov10 RISC complex RNA helicase like 1 −1.17430
350 ADGRE5 adhesion G protein-coupled receptor E5 −1.17397
351 COPB2 coatomer protein complex subunit beta 2 (beta prime) −1.17383
352 NR3C1 nuclear receptor subfamily 3 group C member 1 −1.16742
353 CLEC11A C-type lectin domain family 11 member A −1.16735
354 PI4KB phosphatidylinositol 4-kinase, catalytic, beta −1.16700
355 ACP1 acid phosphatase 1, soluble −1.16609
356 C1QBP complement component 1, q subcomponent binding protein −1.16280
357 PTTG1 pituitary tumor-transforming 1 −1.16060
358 PRRX1 paired related homeobox 1 −1.15954
359 SMAD1 SMAD family member 1 −1.15936
360 ADM adrenomedullin −1.15071
361 NDRG2 NDRG family member 2 −1.14999
362 REST RE1-silencing transcription factor −1.14731
363 NINJ1 ninjurin 1 −1.14059
364 CDKN3 cyclin-dependent kinase inhibitor 3 −1.13962
365 CIB1 calcium and integrin binding 1 −1.13924
366 HSPD1 heat shock protein family D (Hsp60) member 1 −1.13652
367 MS4A4A membrane-spanning 4-domains subfamily A member 4A −1.13410
368 LGALS8 lectin, galactoside-binding, soluble, 8 −1.12928
369 VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) −1.12857
370 PODN podocan −1.12805
371 IL25 interleukin 25 −1.12250
372 TMPRSS4 transmembrane protease, serine 4 −1.12108
373 GRB2 growth factor receptor bound protein 2 −1.11159
374 PEX13 peroxisomal biogenesis factor 13 −1.11146
375 PLCL1 phospholipase C like 1 −1.10743
376 CD48 CD48 molecule −1.10057
377 ASTN1 astrotactin 1 −1.09980
378 IQUB IQ motif and ubiquitin domain containing −1.09258
379 RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived
neurotoxin)
−1.08789
380 AQP4 aquaporin 4 −1.08643
381 PRKCB protein kinase C, beta −1.08474
382 SATB2 SATB homeobox 2 −1.07941
383 GRIA3 glutamate receptor, ionotropic, AMPA 3 −1.06982
384 CCDC39 coiled-coil domain containing 39 −1.06883
385 PECAM1 platelet/endothelial cell adhesion molecule 1 −1.06057