Table 2.
Basic electrophysiological properties of principal neurons in area CA3 in acute hippocampal slices from WT and mice.
| CA3 | WT (n = 21) | (n = 21) | p-value |
|---|---|---|---|
| Series resistance [MΩ] | 19.6±0.8 | 21.6±0.8 | 0.0994 |
| Capacitance [pF] | 137.9±6.5 | 123.2±62 | 0.0741 |
| Input resistance [MΩ] | 331.2±21.6 | 251.3±16.8 | 0.0048** |
| Resting membrane potential [mV] | −66.1±1.4 | −65.2±1.5 | 0.6689 |
| Rheobase [pA] | 125.7±11.1 | 150.0±19.5 | 0.4256 |
| AP no. in ramp based on 1x rheobase | 10.2±1.5 | 7.5±1.0 | 0.2714 |
| Interspike intervals [ms] | 167.2±14.1 | 268.1±58.8 | 0.0536 |
| AP no. in ramp based on 2x rheobase | 23.8±1.6 | 18.8±2.3 | 0.0659 |
| Interspike intervals [ms] | 105.3±15.7 | 235.1±46.7 | 0.0021** |
| AP threshold [mV] | −37.3±1.0 | −39.2±1.0 | 0.2085 |
| AP overshoot [mV] | 57.7±0.6 | 56.8±1.2 | 0.9298 |
| AP afterhyperpolarization [mV] | −50.0±0.7 | −50.7±0.6 | 0.2794 |
| τAHP [ms] | 3.1±0.48 | 3.3±0.36 | 0.3024 |
| AP amplitude [mV] | 94.9±1.5 | 96.0±1.8 | 0.5294 |
| AP duration [ms] | 1.1±0.08 | 1.1±0.06 | 0.2905 |
| Depolarization speed [mV/ms] | 449.4±26.5 | 414.3±25.5 | 0.3651 |
| Repolarization speed [mV/ms] | −74.3±3.9 | −70.6±3.2 | 0.4812 |
Data are presented as mean ± SEM (Mann-Whitney U-test:
**
p <0.01). No correction for multiple comparisons has been performed. Bold values are statistically significant values.