Figure 2.

TAP2 Is Regulated by Progesterone and Is Expressed by DSCs at the Maternal-Fetal Interface

(A–C) Immunohistochemistry staining showing TAP2 localization in the (A) non-pregnant endometrium, (B) pregnant endometrium (decidua), and (C) placenta. Abbreviations are as follows: LE, luminal epithelium; GE, glandular epithelium; ESF, endometrial stromal fibroblast; DSC, decidual stromal cell; and Tr, trophoblast.

(D) Relative expression of TAP2 across the menstrual cycle.

(E) Relative expression of TAP2 in the endometrium of women using either depot medroxyprogesterone acetate (DMPA) or levonorgestrel intrauterine system (LNG-IUS), both progestin-based contraceptives.

(F) Relative expression of TAP2 in ESFs treated with control media or differentiated into DSCs with cAMP and MPA for 48 hr.

(G) Relative expression of TAP2 in cAMP- and MPA-differentiated DSCs treated with a control siRNA or a PGR-specific siRNA (KD).