Figure 5.

The rs2071473 T/C Polymorphism Has Genetic Signatures of Balancing Selection

Fay and Wu’s H statistic, Tajima’s D, F_ST, and nucleotide diversity (pi) for HGDP CEU (green) and YRI (red) populations across the HLA region of chromosome 6. The location of rs2071473 is shown with a vertical red line. LD across this region is shown, LOD scores with white diamonds indicate pairwise D′ values less than 1 with no statistically significant evidence of LD (LOD < 2), light-blue diamonds indicate high D′ values (>0.99) with low statistical significance (LOD < 2), and light-pink diamonds indicate high statistical significance (LOD ≥ 2) but low D′ (<0.5).