Figure 2.

Matrix of Pairwise F_ST of RNF213 across Worldwide Populations

F_ST was calculated for RNF213 common variants from the Omni chip (A) and functional variants from exome sequencing and (B) between each two populations. FC_CTRL and FC_IA are the FC control cohort and the IA cohort, respectively; other populations are indicated by the three-letter codes used by 1KGP. The allele distributions of RNF213 common SNPs vary among populations, suggesting the existence of genetic drift. Among others, there is a big difference in the allelic distributions of RNF213 functional variants between Asians and FC populations.