Table 3.
Mutation Burden of 11 Prioritized Genes between FC IA-Affected and Control Individuals
| Gene |
Risk/Total Allelesa |
VT Statistic | p Value (Unadjusted) | SE | Permutations | |
|---|---|---|---|---|---|---|
| Affected Individuals | Control Individuals | |||||
| ABCA10 | 2/36 | 2/212 | 0.709677 | 0.0775845 | 0.347336 | 5,000 |
| AIM1 | 2/36 | 3/212 | 0.569837 | 0.126873 | 0.339132 | 1,000 |
| CDAN1 | 2/36 | 2/212 | 0.709677 | 0.0771846 | 0.346911 | 5,000 |
| GPATCH8 | 2/36 | 1/212 | 0.903274 | 0.0259948 | 0.345287 | 5,000 |
| HELZ2 | 2/36 | 4/212 | 0.569837 | 0.135864 | 0.340307 | 1,000 |
| OR11H1 | 2/36 | 3/212 | 1.20892 | 0.0195961 | 0.398189 | 5,000 |
| PLEC | 2/36 | 15/212 | 0.121577 | 0.532468 | 0.376399 | 1,000 |
| RNF213 | 5/36 | 4/212 | 1.50576 | 0.00119976b | 0.354706 | 5,000 |
| RTTN | 2/36 | 5/212 | 0.371868 | 0.260739 | 0.344665 | 1,000 |
| SF3A2 | 2/36 | 2/212 | 0.903274 | 0.0313937 | 0.325226 | 5,000 |
| ZNF335 | 2/36 | 1/212 | 0.903274 | 0.0269946 | 0.378224 | 5,000 |
a
Risk alleles are those harboring FC-specific deleterious variants; total alleles include the founder alleles of six IA-affected families.
b
Corrected p = 0.013.