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Celecoxib decreased pERK1/2-positive neurons in the L4-5 spinal cord dorsal horn of OXA-treated mice. (A–C) pERK1/2 immunoreactivities (brown) were detected. Arrowheads indicate representative pERK1/2-positive neurons. Scale bar is 40 µm. (D) The numbers of pERK1/2-positive neurons on one side of the L4-5 spinal cord dorsal horn. Data are shown as the mean ± SD (n = 6). **P<0.01; ***P<0.001 (both vs the vehicles group). ##P<0.01 (vs the OXA+vehicle group).
