Fig. 5.

Summary of phagocyte proteins on Plasmodium development. Phagocyte proteins induced by blood-feeding (possibly by 20E or other blood-meal induced factors), or as a result of unknown stimuli following Plasmodium infection, can significantly influence malaria parasite development in the mosquito. Seven novel proteins were examined in this study that when silenced behaved as agonists (green), antagonists (red), or did not influence parasite development (blue). Five additional proteins, with previously described effects on Plasmodium numbers, also featured prominently in our analysis (denoted by asterisks). Predicted roles are depicted for these phagocyte proteins as cell surface receptors, intracellular signaling, or secreted function.