Skip to main content
. 2016 Sep 22;15(11):3488–3500. doi: 10.1074/mcp.M116.061523

Table I. Antifungal susceptibility of C. albicans in different modes of growth. Two commonly used C. albicans diploids (SC5314 and BWP17) and two standard haploids (GZY792 and GZY803) were used in this study. Fungal cells cultured overnight at 30 °C in GMM (supplemented with required amino acids) were used to prepare the required inoculum for the antifungal susceptibility test. Minimum inhibition concentration (MIC) was recorded by following the CLSI guideline, or optical density (planktonic), or XTT test (biofilm cells).

MIC (μg/ml)
Strains 30 °C
37 °C
Biofilm 107/ml
CLSI 103/ml Planktonic 107/ml CLSI 103/ml Planktonic 107/ml
Amphotericin B
    SC5314 0.25 0.5 0.25 0.5 16
    BWP17 0.25 0.5 0.25 0.5 16
    GZY792 0.25 0.5 0.25 0.5 2
    GZY803 0.25 0.5 0.25 0.5 2
Caspofungin
    SC5314 0.5 2 0.5 2 >32
    BWP17 0.5 2 0.5 2 >32
    GZY792 0.5 2 0.5 2 >32
    GZY803 0.5 2 0.5 2 >32
Fluconazole
    SC5314 0.5 2 0.25 2 >32
    BWP17 0.5 2 0.25 2 >32
    GZY792 0.25 2 0.25 2 >32
    GZY803 0.25 2 0.25 2 >32
Ketoconazole
    SC5314 0.125 0.25 0.125 0.25 >32
    BWP17 0.125 0.25 0.125 0.25 >32
    GZY792 0.125 0.25 0.125 0.25 >32
    GZY803 0.125 0.25 0.125 0.25 >32
Voriconazole
    SC5314 0.006 0.06 0.006 0.06 >32
    BWP17 0.006 0.06 0.006 0.06 >32
    GZY792 0.006 0.06 0.006 0.06 >32
    GZY803 0.006 0.06 0.006 0.06 >32