Table 1.
Upregulated serum proteins in YDH syndrome group quantified by iTRAQ-based proteomics and the ratios to the control group.
| Protein ID | Gene name | Protein name | M/C (114/113) | M/C (116/115) | ||||
|---|---|---|---|---|---|---|---|---|
| Run 1 | Run 2 | Mean | Run 1 | Run 2 | Mean | |||
| P62161 | Calm1 | Calmodulin | 8.09 | 16.75 | 12.42 | 12.82 | 6.08 | 9.45 |
| P62260 | Ywhae | 14-3-3 protein epsilon | 2.68 | 6.31 | 4.49 | 15.28 | 14.59 | 14.93 |
| Q6AYZ1 | Tuba1c | Tubulin alpha-1C chain | 9.29 | 4.79 | 7.04 | 3.91 | 17.22 | 10.56 |
| P45592 | Cfl1 | Cofilin-1 | 4.37 | 3.44 | 3.90 | 11.07 | 13.93 | 12.50 |
| P01048 | Map1 | T-kininogen 1 | 5.50 | 4.57 | 5.03 | 16.29 | 5.65 | 10.97 |
| P09006 | Serpina3n | Serine protease inhibitor A3N | 2.99 | 2.86 | 2.92 | 11.91 | 13.18 | 12.55 |
| P08932 | — | T-kininogen 2 | 3.91 | 4.79 | 4.35 | 14.72 | 6.14 | 10.43 |
| Q62812 | Myh9 | Myosin-9 | 7.11 | 9.55 | 8.33 | 6.79 | 6.03 | 6.41 |
| P18418 | Calr | Calreticulin | 4.13 | 2.75 | 3.44 | 8.55 | 9.73 | 9.14 |
| Q66HD0 | Hsp90b1 | Endoplasmin | 3.02 | 6.25 | 4.64 | 13.55 | 2.03 | 7.79 |
| P34058 | Hsp90ab1 | Heat shock protein HSP 90-beta | 4.25 | 9.64 | 6.94 | 5.25 | 5.50 | 5.37 |
| P68511 | Ywhah | 14-3-3 protein eta | 3.84 | 1.46 | 2.65 | 13.68 | 5.06 | 9.37 |
| P04276 | Gc | Vitamin D-binding protein | 6.61 | 4.45 | 5.53 | 5.65 | 6.03 | 5.84 |
| Q62636 | Rap1b | Ras-related protein Rap-1b | 3.19 | 2.58 | 2.89 | 8.71 | 7.66 | 8.18 |
| Q9Z1P2 | Actn1 | Alpha-actinin-1 | 2.99 | 2.63 | 2.81 | 6.79 | 8.79 | 7.79 |
| P09495 | Tpm4 | Tropomyosin alpha-4 chain | 2.81 | 2.51 | 2.66 | 6.14 | 9.12 | 7.63 |
| Q6PCT3 | Tpd52l2 | Tumor protein D54 | 1.71 | 6.31 | 4.01 | 4.41 | 7.87 | 6.14 |
| P11980 | Pkm | Pyruvate kinase isozymes M1/M2 | 1.82 | 2.56 | 2.19 | 11.27 | 4.57 | 7.92 |
| Q08163 | Cap1 | Adenylyl cyclase-associated protein 1 | 3.22 | 3.94 | 3.58 | 4.17 | 8.39 | 6.28 |
| P11598 | Pdia3 | Protein disulfide-isomerase A3 | 11.17 | 3.16 | 7.17 | 2.13 | 2.27 | 2.20 |
| P16086 | Sptan1 | Spectrin alpha chain | 2.38 | 3.16 | 2.77 | 5.92 | 6.92 | 6.42 |
| P62963 | Pfn1 | Profilin-1 | 3.13 | 2.31 | 2.72 | 4.79 | 7.45 | 6.12 |
| Q68FR2 | Bin2 | Bridging integrator 2 | 2.25 | 2.17 | 2.21 | 6.03 | 6.08 | 6.05 |
| Q63610 | Tpm3 | Tropomyosin alpha-3 chain | 2.21 | 2.70 | 2.46 | 5.30 | 6.25 | 5.77 |
| P06866 | Hp | Haptoglobin | 7.11 | 3.50 | 5.31 | 2.75 | 3.05 | 2.90 |
| P08934 | Kng1 | Kininogen-1 | 5.86 | 4.88 | 5.37 | 1.60 | 2.83 | 2.22 |
| B0BNA5 | Cotl1 | Coactosin-like protein | 2.56 | 2.25 | 2.40 | 5.65 | 4.53 | 5.09 |
| Q63081 | Pdia6 | Protein disulfide-isomerase A6 | 3.02 | 4.21 | 3.61 | 4.29 | 3.44 | 3.86 |
| P85972 | Vcl | Vinculin | 3.56 | 3.08 | 3.32 | 4.09 | 3.94 | 4.02 |
| P04642 | Ldha | L-lactate dehydrogenase A chain | 4.41 | 1.67 | 3.04 | 6.61 | 1.82 | 4.21 |
| P63102 | Msfs1 | 14-3-3 protein zeta/delta | 2.81 | 1.84 | 2.32 | 5.20 | 4.53 | 4.86 |
| B2GUZ5 | Capza1 | F-actin-capping protein subunit alpha-1 | 2.23 | 1.72 | 1.98 | 3.73 | 6.49 | 5.11 |
| P46462 | Vcp | Transitional endoplasmic reticulum ATPase | 2.99 | 2.40 | 2.70 | 2.65 | 5.45 | 4.05 |
| P20767 | — | Ig lambda-2 chain C region | 2.25 | 2.05 | 2.15 | 2.58 | 6.55 | 4.56 |
| Q5XFX0 | Tagln2 | Transgelin-2 | 3.63 | 2.07 | 2.85 | 2.81 | 4.37 | 3.59 |
| Q4V7E8 | Lrrfip2 | Flightless-interacting protein 2 | 2.33 | 1.96 | 2.15 | 4.06 | 3.98 | 4.02 |
| Q63617 | Hyou1 | Hypoxia upregulated protein 1 | 1.79 | 5.97 | 3.88 | 1.75 | 2.58 | 2.17 |
| Q62930 | C9 | Complement component C9 | 3.63 | 2.83 | 3.23 | 2.25 | 3.25 | 2.75 |
| Q5XI73 | Arhgdia | Rho GDP-dissociation inhibitor 1 | 1.74 | 2.99 | 2.37 | 2.96 | 4.02 | 3.49 |
| P04797 | Gapdh | Dehydrogenase | 1.77 | 1.51 | 1.64 | 3.50 | 4.92 | 4.21 |
| Q07009 | Capn2 | Calpain-2 catalytic subunit | 1.28 | 3.60 | 2.44 | 3.80 | 2.65 | 3.23 |
| Q5U211 | Snx3 | Sorting nexin-3 | 1.91 | 4.25 | 3.08 | 1.60 | 3.22 | 2.41 |
| Q63514 | C4bpa | C4b-binding protein alpha chain | 2.99 | 2.49 | 2.74 | 2.88 | 2.31 | 2.60 |
| Q64119 | Myl6 | Myosin light polypeptide 6 | 1.72 | 2.27 | 2.00 | 3.60 | 2.68 | 3.14 |
| P97571 | Capn1 | Calpain-1 catalytic | 3.73 | 2.15 | 2.94 | 2.11 | 1.61 | 1.86 |
| P20760 | Igg-2a | Ig gamma-2A chain C region | 1.50 | 1.84 | 1.67 | 2.63 | 3.22 | 2.93 |
| P06761 | Hspa5 | 78 kDa glucose-regulated protein | 1.56 | 1.46 | 1.51 | 3.53 | 2.56 | 3.05 |
| Q63515 | C4bpb | C4b-binding protein beta chain | 3.60 | 2.09 | 2.84 | 1.56 | 1.61 | 1.59 |
| Q7M0E3 | Dstn | Destrin | 3.16 | 1.29 | 2.23 | 2.61 | 1.58 | 2.10 |
| Q9EPH8 | Pabpc1 | Polyadenylate-binding protein 1 | 1.41 | 1.80 | 1.60 | 3.40 | 2.00 | 2.70 |
| P63018 | Hspa8 | Heat shock cognate 71 kDa protein | 1.60 | 2.19 | 1.89 | 2.63 | 2.17 | 2.40 |
| P04785 | P4hb | Protein disulfide-isomerase | 2.25 | 2.01 | 2.13 | 1.82 | 2.49 | 2.15 |
| Q9EQX9 | Ube2n | Ubiquitin-conjugating enzyme E2 N | 2.86 | 1.58 | 2.22 | 1.87 | 2.15 | 2.01 |
| P06399 | Fga | Fibrinogen alpha chain | 4.37 | 1.43 | 2.90 | 1.33 | 1.28 | 1.31 |
| P01835 | — | Ig kappa chain C region | 2.01 | 1.57 | 1.79 | 2.03 | 2.70 | 2.37 |
| P12346 | Tf | Serotransferrin | 1.60 | 1.91 | 1.75 | 2.54 | 2.03 | 2.28 |
| Q9JLT6 | Bid | BH3-interacting domain death agonist | 1.36 | 1.64 | 1.50 | 1.69 | 3.05 | 2.37 |
| P68101 | Eif2s1 | Eukaryotic translation initiation factor | 1.66 | 1.26 | 1.46 | 3.16 | 1.46 | 2.31 |
| P35213 | Ywhab | 14-3-3 protein beta/alpha | 1.85 | 1.28 | 1.57 | 2.65 | 1.49 | 2.07 |
| Q91ZN1 | Coro1a | Coronin-1A | 1.64 | 1.37 | 1.51 | 2.36 | 1.69 | 2.02 |
| P04906 | Gstp1 | Glutathione S-transferase P | 1.33 | 1.47 | 1.40 | 2.51 | 1.67 | 2.09 |
| P14272 | Klkb1 | Plasma kallikrein | 2.11 | 1.96 | 2.03 | 1.27 | 1.42 | 1.34 |
| P07335 | Ckb | Creatine kinase B-type | 1.41 | 1.28 | 1.34 | 1.57 | 1.38 | 1.48 |
M, model group; C, control group; 114/113 and 116/115, two biological replicates; Run 1 and Run 2, two technical replicates.