Table 1.

Hallmark Gene Sets Significantly Induced, Positive NES^a, or Repressed, Negative NES, after preS1 Treatment in Huh7.5.1-NTCP Cells Shown in Figure 4

Gene Set	NESa	p value	FDRb
Bile acid metabolism	2.32	<0.001	<0.001
Coagulation	2.25	<0.001	<0.001
Xenobiotic metabolism	2.20	<0.001	<0.001
Fatty acid metabolism	2.20	<0.001	<0.001
Heme metabolism	2.04	<0.001	<0.001
Adipogenesis	1.91	<0.001	<0.001
Peroxisome	1.90	<0.001	<0.001
Interferon alpha response	1.90	<0.001	<0.001
Oxidative phosphorylation	1.90	<0.001	<0.001
Estrogen response late	1.89	<0.001	<0.001
Angiogenesis	1.72	0.002	0.003
Cholesterol homeostasis	1.68	0.004	0.005
Hypoxia	1.61	<0.001	0.010
Interferon gamma response	1.60	<0.001	0.009
Reactive oxygen species pathway	1.59	0.013	0.010
Estrogen response early	1.58	<0.001	0.011
Myogenesis	1.57	0.002	0.012
IL2 STAT5 signaling	1.54	<0.001	0.013
IL6 JAK STAT3 signaling	1.54	0.008	0.014
Complement	1.49	0.003	0.021
MTORC1 signaling	−1.50	0.005	0.012
Unfolded protein response	−1.82	<0.001	<0.001
G2M checkpoint	−2.01	<0.001	<0.001
E2F targets	−2.02	<0.001	<0.001
MYC targets V2	−2.54	<0.001	<0.001
MYC targets V1	−2.64	<0.001	<0.001

^aNormalized enrichment score.

^bFalse discovery rate.