Table 1.
Pathways and metabolites altered by mechanical loading. Clusters refer to untargeted clusters identified in Figure 1A.
| Pathways | Cluster | Mechanosensitive Metabolites [KEGG ID] |
|---|---|---|
| Galactose metabolism | 1 | C06376;C00159;C00795;C00267;C01132;C00095;C00124;C00137 |
| 4 | C00243;C05400;C01235;C05402;C00089 | |
| Chondroitin sulfate degradation | 1 | C02336;C00267;C04053;C00532;C10906;C00379;C01132;C03878;C00221; C01904 |
| 3 | C00252;C01083;C00243;C02713;C08240;C08250;C05402;C00089 | |
| 4 | C00252;C01083;C00243;C08240;C08250;C05402;C00089 | |
| Lipid synthesis, transport, and metabolism | 1 | C00267;C01132;C00588;C01582 |
| 2 | C00588;C00157;C00246;C06429 | |
| 3 | C00350;C00157 | |
| 4 | C04230;C00157 | |
| Glycine, serine, and threonine metabolism | 3 | C00263;C05519;C06231;C00188 |
| 4 | C05519;C00263;C00188 |
Cluster 1: increase with loading. Cluster 2: increase after 30 min. loading. Cluster 3: decrease with loading. Cluster 4: Increase after 15 min. loading