Figure 4. Schematic depiction of hepaCAM activities.

(A) HepaCAM associates with connexin 43 at the cell-cell contacts of U373 MG glioblastoma cells. (B) Treatment of cells with antibody against the HepaCAM extracellular domain prevents association of hepaCAM with connexin 43 at cell-cell contacts and downregulates cell surface expression of connexin 43. (C) The R92Q and R92W mutations in the hepaCAM extracellular domain prevent association of hepaCAM with connexin 43 at cell-cell contacts.