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. 2016 Nov 7;6:36687. doi: 10.1038/srep36687

Figure 6. Platelet-derived miR-30c is critical for modulating arterial thrombosis.

Figure 6

(A) Platelet numbers were counted in whole blood drawn from HFD-WT mice. Platelet depletion was achieved by injection of anti-mouse GPIbα rat IgG (n = 11). *P < 0.05 vs. depleted HFD-Pai-1−/− → HFD-WT mice; **P < 0.05 vs. depleted HFD-WT → HFD-WT mice. (B) Mean time to thrombotic occlusion of carotid arteries was measured from the 4 groups of mice generated by the platelet depletion/reinfusion as indicated in the figure. (n = 11/each group). *p < 0.05, lenti-NC injection HFD-WT → HFD-WT vs. lenti-NC injection HFD-Pai-1−/− → HFD-WT mice; **p < 0.05 lenti-miR-30c injection HFD-WT → HFD-WT vs. lenti-NC injection HFD-WT → HFD-WT mice; #p < 0.05, lenti-miR-30c injection HFD-WT → HFD-WT vs. lenti-miR-30c injection HFD-Pai-1−/− → HFD-WT mice.