Figure 6. mPFC damage does not affect recall of learned spatial information, but does impair hippocampal LTP.

(a) QA-injected mice perform equally to sham during 5 days of extended training in the MWM. Platform location is kept in the same position before and after the surgery (time of the surgery indicated by arrow). (b) Heat maps illustrate near identical performance in the two groups in time spent searching the target quadrant during probe tests, (c) No changes in basal synaptic transmission (as shown by the I/O curve) between treatment groups. (d) QA-injected mice expressed only short-lasting potentiation of about 10 min duration, whereas sham mice developed short-term potentiation that returned to baseline after about 35 min.