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. 2016 Nov 7;6:36290. doi: 10.1038/srep36290

Figure 2. MTHFR c.677T variant leads to a notably increased cellular homocysteine level in PCa cell lines.

Figure 2

(A) Knockdown efficiency of shMTHFR and protein expression of MTHFR after restoration of wild-type or mutant MTHFR gene was measured by western blot. The full-length blots were displayed in Supplementary Figure 1. (B) c.677T variant of MTHFR gene leads to an increased cellular homocysteine level in both LNCaP and PC3 cell lines. (C) c.1298C variant of MTHFR gene has no effect on the cellular homocysteine level in LNCaP and PC3 cell lines. ***Indicates P < 0.001, ns indicates no significance.