Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 7;6:36290. doi: 10.1038/srep36290

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) Comet Assay results in control cells. (B) Comet Assay results in MTHFR-knockdown cells, indicating that down-regulation of MTHFR leads to DNA damage. (C) Comet Assay results in MTHFR-knockdown + wild-type overexpressed cells, indicating that overexpression of 677C-MTHFR can reduce DNA damage. (D) Comet Assay results in MTHFR-knockdown + 677T-MTHFR overexpressed cells, indicating that overexpression of 677T-MTHFR cannot reduce DNA damage. (E) Quantitative Comet Assay results in LNCaP cells, indicating that c.677T variant might cause DNA damage compared with wild-type MTHFR. (F) Same results are achieved in PC3 cell lines. Red arrow points out the tails, which indicate DNA damage.