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. 2016 Nov 7;6:36290. doi: 10.1038/srep36290

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Copyright © 2016, The Author(s)

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(A) c.677T variant of MTHFR inhibits cell proliferation significantly compared with wild-type MTHFR in LNCaP cells. (B) c.677T variant of MTHFR inhibits cell proliferation significantly compared with wild-type MTHFR in PC3 cells. (C) c.1298C variant of MTHFR has no significant effect on cell proliferation compared with wild-type MTHFR in LNCaP cells. (D) c.1298C variant of MTHFR has no significant effect on cell proliferation compared with wild-type MTHFR in PC3 cells. *Indicates P < 0.05, **indicates P < 0.01, ***indicates P < 0.001, all comparisons were performed between groups of shMTHFR + wild-type MTHFR and shMTHFR + c.677T/c.1298C MTHFR.